Dapagliflozin for Failing Fontan Circulation
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have had a Fontan procedure (a surgery for a single-ventricle heart condition).
- You have shortness of breath (NYHA class II-IV) that is not from another cause like lung disease or a heart attack.
- You have high pressure in your veins as measured during a test (≥20 mmHg).
- You are not taking certain medications like insulin, empagliflozin, or canagliflozin, and you do not have type 1 diabetes or severe kidney/liver disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether dapagliflozin, a diabetes drug that also helps the heart, can improve exercise ability and heart function in people who have had the Fontan procedure for a single ventricle heart defect.
This trial tests if a diabetes medicine called empagliflozin can help people with Fontan circulatory failure feel better and do more of their daily activities.
This study tests whether a medicine called dapagliflozin can improve heart function in people hospitalized with acute heart failure. It may help the heart pump more efficiently and improve recovery.
This study tests whether a diabetes medicine called dapagliflozin can help people with pulmonary hypertension. It may improve symptoms and heart function, and the trial will monitor safety and effectiveness.
This study tests whether a daily pill called dapagliflozin can reduce chest pain and improve blood flow in people who have chest pain but no major blockages in their heart arteries. It may help if your heart's small blood vessels are not working properly.
This trial tests whether a diabetes medication called dapagliflozin can help improve how well the right side of your heart works after off-pump coronary artery bypass grafting surgery (a way to reroute blood around blocked heart arteries). The goal is to see if this drug reduces strain on your heart during recovery.
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