Can dapagliflozin help liver cirrhosis with fluid buildup? (Phase 2/3 randomized trial)
Treatments studied
Part of Digestive system clinical trials.
This trial tests a diabetes pill (dapagliflozin) to see if it helps people with liver cirrhosis and fluid buildup (ascites). The goal is to improve fluid balance and possibly reduce hospital stays.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older with liver cirrhosis and fluid buildup in your abdomen (ascites) that has required you to be in the hospital, now or in the past.
- Your liver disease is not too advanced (Child-Pugh score below 12 and MELD score 25 or less).
- You do not have a history of very low blood sugar or diabetic ketoacidosis.
- Your blood pressure is 90/60 or higher, and you do not need more than one strong blood-pressure raising medicine daily.
- You have not had more than 2 urinary tract infections in the last 6 months, and you have no structural problems in your urinary tract (like blockages or defects).
- You are not pregnant, breastfeeding, allergic to dapagliflozin, and your kidney function is good (eGFR 30 or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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