IV Tylenol to reduce opioid use after surgery
Treatments studied
Part of Brain & nervous system, Pain clinical trials.
This study tests whether giving acetaminophen (Tylenol) through an IV (into a vein) after abdominal surgery can help reduce the need for stronger opioid painkillers. It is for patients who cannot take pills or liquids by mouth right after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had planned (elective) abdominal surgery.
- You are staying in a specific unit at CHUM (digestive surgery, hepatobiliary/pancreatic surgery, or gynecology/gynecologic oncology).
- Right after surgery, you cannot take medications by mouth (NPO).
- You are not allergic to acetaminophen (Tylenol).
- You do not have a serious liver condition (Child-Pugh B or C).
- You weigh at least 50 kg (about 110 pounds).
- You are not pregnant or breastfeeding.
- You are not being treated for opioid use disorder.
- You have not taken long-acting opioids in the 7 days before surgery.
- You do not use illegal recreational drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a high dose of oral paracetamol (Tylenol) given before tonsillectomy surgery can reduce pain after the operation in children. It aims to find a safe and effective way to manage pain without opioids.
This trial tests if giving acetaminophen (Tylenol) through a vein after heart surgery can help patients recover better. You may be a good fit if you are having planned heart surgery that is not an emergency.
This trial tests whether acetaminophen (a common pain reliever) works better than a placebo (a sugar pill) for pain after abdominal surgery. If you join, you will receive either the study drug or a placebo to help understand the best way to manage pain.
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
This study tests whether giving acetaminophen (Tylenol) through an IV (a vein) instead of by mouth helps reduce pain and fussiness after tonsil and adenoid removal in children age 7 and under. The goal is to find better ways to keep children comfortable during recovery.
This study compares different pain medicines to see which works best and is safest for children after surgery for tonsil removal, gallbladder removal, or knee arthroscopy. It aims to help find the most effective and least risky pain control option.
Hear when a new Post Operative Analgesia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.