Tracking stem cells in people with radiation proctitis
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether a special kind of stem cell (called TH-SC01) can help people with long-term rectal damage from pelvic radiation. You will be injected with a small amount of radioactive material attached to the cells so doctors can see where they go and how long they stay in your body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had pelvic cancer treated with radiation more than 6 months ago.
- You have chronic proctitis (rectal inflammation) that hasn't improved with standard treatments.
- A colonoscopy confirmed the diagnosis.
- Doctors rated your proctitis symptoms at a specific level (LENT-SOMA score of 1 or higher but not the worst level of 4) during the screening.
- You are in good overall physical condition (able to do most normal activities).
- You agree to use effective, non-hormonal contraception if needed and not plan pregnancy during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a dietary supplement to help heal damage inside the rectum caused by pelvic radiation therapy. If you have mild to moderate rectal bleeding but no signs of cancer recurrence, you may be able to join.
This study tests whether a single injection of special cells (umbilical cord stem cells) can help heal long-term inflammation in the rectum caused by previous pelvic radiation. It's for people whose standard treatments have not worked.
This trial tests whether a special type of stem cells (from umbilical cord blood) can help heal chronic bowel damage caused by radiation therapy. It is for people whose bowel symptoms, like diarrhea or pain, continue despite standard treatment.
This trial tests a new treatment using special stem cells (modified to boost your immune system) for people with advanced colorectal cancer. It is for patients who are 18 or younger and whose cancer has not responded to or cannot be treated with standard therapies.
This study tests whether a fecal (stool) transplant can help heal rectal damage caused by pelvic radiation. The treatment may decrease bleeding and improve symptoms for people whose supportive care hasn't worked well.
This trial tests a shorter course of radiation therapy followed by a combination of chemotherapy, immunotherapy, and a pain-relief medication, compared to the standard approach. It is for people with a certain type of rectal cancer that has not spread.
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