Testing brain-gut medicines for stomach discomfort
Treatments studied
Part of Brain & nervous system, Digestive system clinical trials.
This trial tests whether medications that affect the link between the brain and the gut can improve symptoms of functional dyspepsia (a condition causing stomach pain and discomfort without an obvious cause). It may help if other treatments haven't worked well.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with functional dyspepsia using the Rome IV criteria (a standard medical definition).
- You can complete surveys and sign a consent form.
- You have not had any other stomach or intestine problems found during an upper endoscopy in the last 6 months.
- You do not have serious heart, liver, kidney, or lung conditions.
- You are not allergic to the study medications, and you are not pregnant, breastfeeding, or planning to become pregnant.
- You have not taken monoamine oxidase inhibitors (a type of antidepressant) in the past 5 weeks, and you are not at risk for narrow angle glaucoma.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a combination of two medications, amitriptyline and trifluoperazine, can help patients with ongoing discomfort in the upper stomach (functional dyspepsia). It may be an option if other treatments haven't worked.
This study tests whether a tailored diet can improve symptoms in people with functional dyspepsia (stomach discomfort without a clear physical cause). It also uses a special in-hospital camera exam to look at the stomach lining and understand how the diet affects you.
This study uses brain scans (MRIs) and a test meal to understand how the brain and stomach communicate in people with functional dyspepsia (ongoing pain or fullness). This could help improve treatments by identifying how people with this condition feel and process stomach sensations differently.
This trial studies whether EDL medicine can improve symptoms of functional dyspepsia (indigestion) and is safe for people with this condition. You may be asked to complete symptom questionnaires and undergo stomach testing to confirm there is no other cause for your symptoms.
This study tests if a mobile app teaching cognitive behavioral therapy (a way to change thinking patterns) can help people with stubborn stomach pain or discomfort. It might benefit those whose symptoms haven't improved with usual medicines.
This study is testing whether a probiotic supplement can help relieve symptoms of functional dyspepsia (stomach pain, fullness, or burning without a clear cause). It is for people who have moderate to severe symptoms and have not taken certain medications or supplements recently.
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