A study on megestrol acetate for weight loss in advanced digestive cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This study tests a special form of megestrol acetate (a medicine that can help with appetite and weight gain) in people with advanced digestive system cancers who are about to start or are already taking a type of targeted therapy called a TKI. The goal is to see if it helps with cancer-related weight loss and wasting (cachexia).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You have an advanced digestive system cancer that cannot be cured with surgery or other local treatments.
- You are scheduled to receive or are currently receiving a TKI-based cancer treatment (possibly with chemotherapy or immunotherapy).
- You have been diagnosed with pre-cachexia or cachexia (unintentional weight loss and muscle wasting related to your cancer).
- You are able to take care of yourself (ECOG score 0–2) and your doctor expects you to live at least 3 more months.
- You do not have a bowel blockage, severe heart/kidney/liver disease, or a major surgery in the last month.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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