Vitamin B12 pill vs under-the-tongue for low B12 from acid medicine
Treatments studied
This trial tests two ways to take vitamin B12 — as a pill you swallow or as a liquid under your tongue — to see which works better for people whose stomach acid medicine (PPIs) may have made their B12 levels drop. If you qualify, you'll take one of these for 6 weeks, and the study will track your B12 levels to see if they improve.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have been taking a proton pump inhibitor (such as omeprazole or esomeprazole) for 1 to 6 months.
- Your vitamin B12 level is slightly low (between 150 and 300 pg/mL), but you have not taken B12 supplements yet.
- You do not have long-term digestive diseases like Crohn's or celiac disease.
- You have not had stomach or weight-loss surgery, and you do not have severe kidney, liver, or anemia problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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