Eye drops study for Fuchs corneal disease and glaucoma
Part of Eyes & vision, Genetic & congenital clinical trials.
This study tests whether special eye drops (Rho-kinase inhibitors) can improve the health of the cornea in people who have both Fuchs endothelial corneal dystrophy and glaucoma. The drops may help reduce corneal swelling and preserve your vision.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 40 and 90 years old.
- You have been diagnosed with Fuchs endothelial corneal dystrophy (FECD) and glaucoma.
- Your cataract (if present) must be grade II nuclear/cortical or posterior subcapsular, as assessed by your doctor.
- You do not have other eye problems like pseudoexfoliation syndrome or corneal opacities.
- Your eye is not currently inflamed on the surface.
- You have not had any prior eye injury or surgery on the eye being studied.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 study tests whether eye drops containing a medicine called N-acetylcysteine (NAC) can reduce damaging “reactive oxygen” in people with advanced Fuchs’ endothelial corneal dystrophy (FECD). It involves people who need a special cornea transplant (DMEK) at the same time as cataract surgery, aiming to improve cornea healing and vision.
This study tests a scoring system to predict how well people with Fuchs dystrophy do after cataract surgery. It may help doctors plan better treatment for your cornea and lens.
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This trial tests a surgical technique called Descemet membrane polishing during corneal transplant surgery for Fuchs endothelial corneal dystrophy, a condition that clouds the cornea (the clear front part of your eye). The study aims to see if this polishing step improves healing and vision after surgery.
This trial tests a special intraocular lens that works with a cornea transplant procedure (DMEK) for people who have both cataracts and Fuchs' endothelial corneal dystrophy. It aims to see if this lens improves vision and reduces the need for glasses.
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