Study of DT-168 for corneal transplant patients with Fuchs dystrophy
Part of Eyes & vision, Genetic & congenital clinical trials.
This trial tests an investigational eye drop (DT-168) in people with Fuchs endothelial corneal dystrophy who are already scheduled for a corneal transplant. The goal is to see if DT-168 can improve outcomes or delay the need for surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled to have a corneal transplant (keratoplasty) for Fuchs dystrophy.
- You are 30 years or older.
- You have a confirmed diagnosis of Fuchs dystrophy in the eye being studied.
- You have a specific genetic change (TCF4 CTG repeat expansion) related to Fuchs dystrophy.
- You are not using certain eye drops like Muro 128 or steroid drops during the study, or you can stop them before starting.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
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This Phase 3 trial compares outcomes from two cornea transplant procedures in people with FECD, a disease that makes the cornea swell and affect vision. It may help you and others by identifying which approach best supports clear vision and stable corneal thickness after surgery.
This study tests whether special eye drops (Rho-kinase inhibitors) can improve the health of the cornea in people who have both Fuchs endothelial corneal dystrophy and glaucoma. The drops may help reduce corneal swelling and preserve your vision.
This trial tests a surgical technique called Descemet membrane polishing during corneal transplant surgery for Fuchs endothelial corneal dystrophy, a condition that clouds the cornea (the clear front part of your eye). The study aims to see if this polishing step improves healing and vision after surgery.
This study looks at how the cornea (the clear front part of the eye) changes after cataract surgery in people with Fuchs' endothelial dystrophy, a condition that affects the inner layer of the cornea. It compares them to people without this condition to see if there are differences in corneal thickness after surgery.
This Phase 2 study tests whether eye drops containing a medicine called N-acetylcysteine (NAC) can reduce damaging “reactive oxygen” in people with advanced Fuchs’ endothelial corneal dystrophy (FECD). It involves people who need a special cornea transplant (DMEK) at the same time as cataract surgery, aiming to improve cornea healing and vision.
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