Eye Drop for Nerve-Damaged Corneas
Part of Eyes & vision clinical trials.
This trial tests an experimental eye drop (STSP-0902) for a condition called neurotrophic keratitis, where the cornea (the clear front part of the eye) gets scratches or sores because nerves are damaged. The drop contains a growth factor to help the eye heal. You might be eligible if you have a persistent scratch or sore on your cornea that has not improved for at least a week.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 to 85 years old.
- Your eye with nerve damage must have a certain size scratch (at least 2 mm) that has not healed for at least 2 weeks.
- The surface of your eye must be numb or less sensitive than normal in the damaged area and at least one nearby section.
- You cannot have an active eye infection, uncontrolled eye inflammation, or other eye diseases that need separate drops.
- You cannot use certain eye drops (corticosteroids, NSAIDs, or growth-factor drops) a week before starting or during the study.
- You must agree to use reliable birth control and not plan pregnancy for the study period and 3 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a new eye drop called Lacripep can help treat neurotrophic keratitis, a rare eye condition where the cornea loses sensation and can become damaged. The study compares Lacripep to a placebo (inactive) drop to see if it improves corneal healing and vision.
This Phase 2 trial tests BRM424 eye drops in adults with neurotrophic keratitis (a weakened, slow-healing cornea) to see if they help and are safe over 28 days. You may be able to join if your condition matches Stage 2 or Stage 3 and you meet the safety rules.
This study compares two treatments for neurotrophic keratitis, a condition where the cornea loses sensation. One treatment is a surgery to reconnect nerves to the eye, and the other is a special eye drop called Cenegermin. The goal is to see which works better to heal the cornea.
This trial tests whether KB801 can help heal persistent corneal defects better than a placebo. It is for people with neurotrophic keratitis (a condition where the cornea loses sensation) that has not improved with standard care.
This Phase 3 trial tests whether a 0.1% RGN-259 eye drop can safely improve a stubborn corneal wound in adults with neurotrophic keratopathy (nerve-related corneal healing problems). You may qualify if you still have an eye surface defect after at least a week of standard treatments, and you meet specific measurements for corneal sensitivity and vision.
This trial tests a new eye drop (acoltrepon) to see if it helps people with stage 1 neurotrophic keratopathy (a condition where the cornea's nerves are damaged, causing dry eyes and vision problems) and low tear production. It aims to improve signs like corneal staining and symptoms of discomfort.
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