Gene-edited liver transplant to lower rejection risk
Part of Cancer, Digestive system clinical trials.
This trial tests a liver transplant using a donor organ that has been gene-edited to reduce the risk of rejection. It may help people who need a liver transplant and are not a perfect tissue match with their donor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 16 and 85 years old.
- You have end-stage liver disease or acute liver failure and are on the waiting list for a liver transplant.
- You will receive a donor liver that is not a perfect tissue match (this is typical for most liver transplants).
- You are healthy enough for surgery and can take standard anti-rejection medicines.
- You are willing to have extra biopsies and blood tests for long-term follow-up.
- You are not pregnant, breastfeeding, or needing a transplant of another organ at the same time.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new way to preserve donated livers before transplant, which may help people with severe liver disease get a transplant sooner. It may be an option for patients with certain cancers or urgent liver failure.
This study tests a new way to check donated livers that other transplant centers have turned down. The goal is to see if these livers can be safely used for people on the waiting list, potentially increasing the number of available organs.
This study tests if some liver transplant patients can safely take lower doses of their immune-suppressing medicines, potentially reducing side effects. It uses a biomarker test to guide the treatment changes.
This trial studies liver transplantation for certain people with colorectal cancer that has spread only to the liver and cannot be removed with surgery. It aims to improve outcomes for carefully selected patients whose cancer is controlled on chemotherapy and who meet specific safety and scan requirements.
This trial tests a specially edited donor kidney designed to reduce the chance of rejection, especially for people with high sensitivity to donor kidneys. If it works, it could make more kidneys available for those who have a hard time finding a match.
This trial is testing a new way to see how well patients do after a liver transplant. It includes people with severe cirrhosis, other end-stage liver diseases, or liver cancer.
Hear when a new Liver Diseases trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.