Testing discarded livers with machine perfusion
Part of Digestive system clinical trials.
This trial tests if a machine that pumps warm oxygenated blood through livers that were considered unsuitable for transplant can help doctors decide if they are actually safe to transplant. If so, it could increase the number of available livers for people waiting for a first liver transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- This trial is for people waiting for their first liver transplant (not a re-transplant or emergency transplant).
- Your kidney function must be reasonably good (GFR of 60 or higher).
- Your MELD score (a measure of liver disease severity) must be 25 or less.
- You must be able to attend follow-up appointments and sign a consent form.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether using a machine to keep donated livers healthy (normothermic machine perfusion) can allow more people to receive a transplant sooner. It is for patients who are already on the waiting list for a liver and have a moderately severe MELD score (25 or less).
This trial tests a new way to check if a donated liver is healthy while it is kept on a machine that keeps it alive before transplant. Doctors measure a substance called FMN in the fluid that flows through the liver and in bile. This could help them know how well the liver might work after transplant.
This study tests a new way to preserve donated livers (called machine perfusion) after they are recovered from donors who died from circulatory causes. It aims to see if this method helps the liver work better before transplant.
This trial tests a special preservation machine that keeps donor livers cold and functioning during transport before transplant. The goal is to improve how well donated livers work after transplantation and reduce complications.
This study tests a new way to preserve donated livers that have extra fat (steatotic livers) using a special machine that keeps the liver healthy outside the body. If successful, it could allow more livers to be used for transplantation, helping people on the waiting list get a transplant sooner.
This study tests whether a special way of moving blood through the donor abdomen before surgery can improve liver (and other organ) transplant quality. It may help because doctors can check how well the liver seems to be working before it’s actually used.
Hear when a new Organ Transplantation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.