Testing immunotherapy for ctDNA-positive colorectal cancer after treatment
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial is for people with colorectal cancer whose ctDNA blood test is still positive after surgery and chemotherapy. It tests two immunotherapy drugs (cemiplimab alone or with fianlimab) to see if they can eliminate the remaining cancer cells and prevent the cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had surgery to remove your colorectal cancer and at least 3 months of chemotherapy afterward.
- A blood test after your treatment shows tiny bits of cancer DNA (ctDNA) still present.
- Your tumor type is MSS (microsatellite stable) or pMMR (proficient mismatch repair).
- You are in generally good health (able to do daily activities) and your blood counts, liver, and kidney function are within safe limits.
- You have not had immunotherapy or other cancer treatments in the last 4 weeks, and you don't have an active autoimmune disease or serious infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This trial tests a personalized immune therapy (like a custom vaccine) for people with colorectal cancer that has a positive ctDNA MRD test after surgery. It aims to use the body's own immune system to target any remaining cancer cells and prevent the cancer from coming back.
This trial tests two immunotherapy drugs (cemiplimab and fianlimab) before surgery for colon cancer that hasn't spread. It's for people with a specific tumor type (pMMR/MSS) who are candidates for surgery.
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This trial tests a mix of three drugs (sintilimab, bevacizumab, and decitabine) for people with advanced colorectal cancer that has a stable or low amount of genetic change. It’s for those whose cancer has grown after at least two prior treatments, and who have not had immunotherapy before.
This trial tests a combination of a targeted therapy pill (TKI) and an immunotherapy (PD-1 inhibitor) for people with advanced colorectal cancer that has stopped responding to standard treatments. It uses a blood test to tailor the treatment, aiming to be more effective with fewer side effects.
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