Clinical trials
Colo-rectal Cancer clinical trials
Below are recruiting colo-rectal cancer clinical trials, each written for real people, not researchers. We’re tracking 40 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03280511RecruitingPhase 2
After surgery chemo sprayed into the abdomen for high-risk colon cancer
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
OdenseAges 18 years+ - NCT04842812RecruitingPhase 1
Personalized immune cell therapy for advanced solid tumors
This Phase 1 study tests engineered immune cells (TILs/CAR-TILs) made from your tumor to treat advanced solid cancers that have not responded to standard treatments. It may help your immune system better recognize and attack the cancer, but it is mainly focused on safety and early results.
GuangzhouAges 18–85 - NCT03755739RecruitingPhase 2/Phase 3
Checkpoint cancer drug given into or near tumors
This trial studies whether giving immunotherapy “checkpoint inhibitor” medicine directly into the tumor area (and/or the artery feeding it), along with a chemotherapy-style drug, can work better for advanced solid tumors. It aims to boost the immune system’s ability to attack cancer while still being safe for people with measurable tumors.
Guanzhou, GuangdongAges 18 years+ - NCT06576986Recruiting
Can a supplement prevent mouth sores during chemo?
This trial tests whether a special supplement (synbiotic) can prevent mouth sores caused by chemotherapy in people with colorectal cancer. It's for those starting treatment who live in or near Belo Horizonte, Brazil.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT06646341Recruiting
Can scan findings predict colorectal cancer spread?
This study looks at whether signs of blood vessel involvement (called EMVI) seen on scans can predict if colorectal cancer spreads to other organs. You might join if you already had surgery to remove the cancer from the colon or rectum and any distant tumors, and your before-surgery scans are available for review.
Basingstoke, HampshireAges 16–100 - NCT04103372Recruiting
MRI check for early rectal cancer or large polyps
This trial uses a special MRI before treatment to better understand early rectal cancer or suspicious large polyps. It may help doctors choose care that avoids bigger surgery when possible.
Reading, BerkshireAges 16–100 - NCT07638410Recruiting
Getting fit before major cancer surgery
This trial tests whether special preparation exercises and wellness support before chemotherapy and major abdominal or pelvic surgery can help you recover better and stay stronger. You'll work with a team including exercise specialists and mental health counselors before your operation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07503847Enrolling by invitation
Colorectal Cancer Screening for Ages 40-49 with Family History
This trial helps people aged 40-49 who have a parent, sibling, or child with colorectal cancer decide on the best way to get screened. It aims to find the most effective screening method for those at higher risk.
TaipeiAges 40–49 - NCT06787625Recruiting
Growing tumor models from colorectal cancer and liver metastases
This study takes samples from colorectal cancer that has spread to the liver and grows them in the lab. The goal is to create models that can help researchers understand the cancer better and find new treatments.
RomeAges 18 years+ - NCT07469709Recruiting
Cancer risk study using genetics and monitoring
This study looks at genetic and other factors in people with certain cancers to better understand personal cancer risks and improve monitoring. It may help find ways to detect changes earlier.
Candiolo, TurinAges 18 years+ - NCT07470658Enrolling by invitation
Surveillance after positive FIT and normal colonoscopy
This trial studies the best way to follow up with people who had a positive FIT stool test (high blood level) but a normal colonoscopy. It aims to find the right schedule for future screening to catch any problems early.
TaipeiAges 45–74 - NCT07450612Recruiting
Blood test and AI for early colorectal cancer detection
This study uses a simple blood test (liquid biopsy) and computer analysis to find early signs of colorectal cancer, precancerous growths, and Lynch syndrome. It aims to improve early detection and monitor for any remaining cancer after treatment.
Milan, LombardyAges 18 years+ - NCT07345676Recruiting
Helping patients complete colorectal cancer screening
This trial is testing a simple program to help people who are due for colorectal cancer screening to complete their test. It's for patients at Cornell Scott Hill Health who either haven't finished a screening order or had an abnormal stool test without follow-up.
New Haven, ConnecticutAges 45–75 - NCT07352280Recruiting
Immunotherapy before surgery for certain colorectal cancers
This trial tests a new immunotherapy drug (tislelizumab) given before surgery for people with stage II or III colorectal cancer that has a specific DNA repair problem (dMMR/MSI-High). The drug aims to shrink the tumor and improve treatment outcomes.
Beijing, UndefinedAges 18 years+ - NCT07223424RecruitingPhase 2
Patient preference study: shot vs infusion for immunotherapy
This study compares two ways to take immunotherapy drugs (nivolumab or pembrolizumab): as a shot under the skin (subcutaneous) versus an infusion into a vein (intravenous). It looks at which method patients prefer and is for people with certain advanced cancers where these drugs are already approved.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07145255RecruitingPhase 1/Phase 2
Study of MBRC-201 for advanced solid tumors
This trial tests a new drug, MBRC-201, for people with advanced solid tumors that have not responded to standard treatments. The goal is to find the best dose and see if it helps shrink tumors or slow their growth.
San Francisco, CaliforniaAges 18 years+ - NCT07148297Recruiting
Blood test for colorectal cancer detection
This study tests a new blood test that might help detect colorectal cancer. If you're already planning a colonoscopy or colorectal surgery, your participation could help improve early detection.
MendozaAges 45–75 - NCT06965335Recruiting
Early-onset colorectal cancer study
This study looks at colorectal cancer that starts early in life (ages 18–40). It compares it to the same cancer in people over 60 to find differences. You can join if you have had colorectal cancer and can provide a sample of your tumor.
Milan, MilanoAges 18–40 - NCT06332274RecruitingPhase 3
Tislelizumab for cancer patients with minimal residual disease
This trial is for people who have completed standard cancer treatments (like surgery, chemo or radiation) and have no visible cancer on scans, but may still have very small amounts of cancer DNA in their blood. The study tests whether the drug tislelizumab can help prevent the cancer from coming back.
Villejuif, Val De MarneAges 18 years+ - NCT07085091RecruitingPhase 1
Study of ALX2004 for advanced solid tumors
This trial tests a new drug, ALX2004, for people with certain advanced cancers (head and neck, lung, esophagus, or colorectal) that have stopped responding to standard treatments. The goal is to see if the drug is safe and effective.
La Jolla, CaliforniaAges 18 years+ - NCT07085169RecruitingPhase 2
Low-dose chemo combo for advanced colorectal cancer
This trial tests a lower dose of a chemotherapy pill (trifluridine/tipiracil) combined with bevacizumab for advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if this combination can help control the cancer with fewer side effects.
SanmingAges 60 years+ - NCT07058012RecruitingPhase 2
Testing immunotherapy for ctDNA-positive colorectal cancer after treatment
This trial is for people with colorectal cancer whose ctDNA blood test is still positive after surgery and chemotherapy. It tests two immunotherapy drugs (cemiplimab alone or with fianlimab) to see if they can eliminate the remaining cancer cells and prevent the cancer from coming back.
Gainesville, FloridaAges 18 years+ - NCT07046585Recruiting
Blood test for colon cancer screening
This trial tests a new blood test to screen for colorectal cancer in people at average risk. You would give a blood sample before your scheduled colonoscopy, and the results will be compared to the colonoscopy findings.
Austin, TexasAges 40 years+ - NCT07003022RecruitingPhase 2
Two-drug combo for advanced colorectal cancer
This trial tests a combination of two drugs (cadonilimab and an anti-angiogenic agent) for advanced colorectal cancer that has a specific genetic feature (dMMR or MSI-H). It aims to find a new treatment option that might work better than current therapies.
Shanghai, ChinaAges 18–80
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Colo-rectal Cancer trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for colo-rectal cancer?
- Yes. Clin2 currently lists 40 recruiting colo-rectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colo-rectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colo-rectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.