Radiation therapy after surgery for head and neck cancer
Part of Cancer clinical trials.
This trial tests whether giving radiation therapy in a specific way (compartmentalized) after surgery for head and neck cancer is safe and effective. It is for people with certain types of head and neck cancer that have been removed, and aims to improve outcomes while managing side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have a performance status (ECOG) of 0, 1, or 2.
- You have squamous cell carcinoma of the mouth, throat, voice box, or pharynx that was surgically removed.
- If you had prior chemotherapy or immunotherapy before surgery, it must have been standard care, not experimental.
- You are able to undergo radiation therapy to the head and neck area, and any additional treatment if needed.
- You have had a recent physical exam and imaging (CT, MRI, or PET) as part of your workup.
- If you are a woman who can become pregnant, you are not pregnant and agree to use effective birth control during and for 1 month after radiation. If you are a man, you agree not to father a child during and for 3 months after radiation.
- You are willing and able to give written informed consent.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether changing the “radiation volume” (how much area is treated) can better preserve swallowing after surgery for oral cavity squamous cell cancer. It may help reduce swallowing problems while still treating the cancer safely.
This trial tests whether patients with early-stage oral cancer who have surgery and lymph-node removal can skip radiation to the neck if certain favorable conditions are met. The goal is to reduce side effects like difficulty swallowing while keeping cancer control strong.
This trial tests a precise type of radiation called stereotactic radiosurgery for people with head or neck tumors. It may be an option for those who need radiation or chemoradiation as their main treatment or after surgery.
This trial looks at whether giving less (de-escalated) radiation after surgery is as effective and safer for people with locally advanced head and neck squamous cell carcinoma who had a strong response to treatment before surgery. If you had no remaining cancer or only very small amounts of cancer left in the surgical specimen, this approach may help reduce side effects while keeping control of the disease.
This trial tests a new combination for people whose head and neck cancer has come back after prior radiation. You'll receive an immunotherapy drug (pembrolizumab) plus radiation, then surgery. The goal is to see if this approach can improve how well surgery works.
This trial tests a combination of two drugs—an immunotherapy (PD-1 inhibitor) and a targeted therapy (cetuximab)—given before surgery to shrink advanced head and neck cancers. The goal is to see if this approach can lower the risk of the cancer coming back.
Hear when a new Head and Neck Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.