Baclofen for persistent heartburn or regurgitation
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether the drug baclofen can help patients who still have acid reflux symptoms (heartburn or regurgitation) despite taking standard treatments like PPIs for 8 weeks. If you've tried PPIs and still have symptoms, this may be an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have ongoing heartburn or regurgitation even after taking standard reflux medication (PPI) for at least 8 weeks.
- You do not have any concerning symptoms like trouble swallowing, unexplained weight loss, bleeding, vomiting, or anemia.
- Your GERD symptom score (GERD Q) must be 8 or more.
- You do not have an active stomach or duodenal ulcer or other serious esophagus conditions.
- You are not pregnant or breastfeeding, and you do not have kidney problems or uncontrolled thyroid/diabetes issues.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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