Melatonin and numbing injection for pain after ACL surgery
Treatments studied
Part of Bones, joints & muscles, Injuries & trauma, Pain clinical trials.
This study tests whether taking a melatonin pill before surgery, combined with a numbing injection in the knee, provides better pain relief after ACL reconstruction. It may help reduce discomfort and the need for stronger pain medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are having keyhole surgery to rebuild the ACL in one knee only.
- You will be awake during surgery with numbing medicine in your spine (spinal anesthesia, not general anesthesia).
- You do not have a chronic pain condition, and you do not take strong painkillers regularly.
- You do not have diabetes, severe high blood pressure, liver or kidney problems, or a known allergy to melatonin.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests two ways to manage pain after ACL reconstruction: a combination of medications (multimodal analgesia) versus a nerve block in the thigh (femoral block). The goal is to see which approach provides better pain control and recovery.
This trial tests whether a single dose of methylprednisolone (a steroid) can reduce pain after ACL knee surgery. You will be randomly assigned to receive either the steroid or a placebo, and your pain levels will be tracked.
This trial tests whether adding dexmedetomidine to a numbing injection (bupivacaine) inside the knee joint provides better pain relief after arthroscopic ACL reconstruction. It aims to help patients recover more comfortably after surgery.
This study compares two different groups of numbing injections to find which works better for pain after ACL knee surgery. The goal is to help you recover with less pain and fewer side effects.
This study looks at ways to manage pain in adults who are getting surgery to repair a torn ACL (a knee ligament). It may help improve comfort and recovery after ACL reconstruction.
This study tests pain management options after ACL reconstruction to reduce the need for strong painkillers. It may help you recover with fewer side effects and lower risk of opioid dependence.
Hear when a new Pain Relief After Arthroscopic Anterior Cruciate Ligament Reconstruction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.