Treatment
Melatonin clinical trials
We’re tracking 67 recruiting studies that include Melatonin, each written for real people, not researchers, below.
Recruiting studies
- NCT07120880RecruitingPhase 3
Light therapy timing for depression with insomnia
This trial tests whether giving light therapy at a specific time of day can improve both depression and sleep problems. It is for adults with major depression and insomnia who are not currently on antidepressants.
ParisAges 18–65 - NCT06489327Recruiting
Melatonin before surgery for children
This trial tests two different doses of oral melatonin (a natural sleep hormone) given to children before surgery to help them relax. It may help your child feel calmer before their procedure.
Cairo, Cairo GovernorateAges 4–10 - NCT06768580Recruiting
Melatonin or lidocaine to prevent confusion after hip replacement
This trial tests if giving either oral melatonin or lidocaine during surgery can reduce the chance of confusion (delirium) in older adults after total hip replacement. It compares these two approaches to standard care.
Tanta, El-GharbiaAges 65 years+ - NCT06801379RecruitingEarly Phase 1
Inhaled melatonin spray for adults with insomnia
This trial tests a new inhaled form of melatonin, a natural sleep hormone, for adults aged 55 and older with insomnia. It aims to see how the medication works in the body and if it can help you fall asleep faster.
Macquarie Park, New South WalesAges 55 years+ - NCT06802913RecruitingEarly Phase 1
Inhaled melatonin for sleep problems in older adults
This trial tests a new inhaled form of melatonin to help adults aged 55 and older with insomnia fall asleep faster. It compares the inhaled melatonin to a placebo to see if it improves sleep and is safe.
Macquarie Park, New South WalesAges 55 years+ - NCT07344467Recruiting
Melatonin vs. Pregabalin for pain and anxiety after spine surgery
This trial compares two medications—melatonin and pregabalin—to see which works better at reducing pain and anxiety after spine surgery. It aims to find a safer, effective option for recovery.
Tanta, El-GharbiaAges 21–60 - NCT07345715Recruiting
Melatonin vs. dexmedetomidine for preventing agitation after tonsil surgery in children
This study tests whether giving children either oral melatonin or a nebulized sedative (dexmedetomidine) before surgery can reduce confusion and restlessness (emergence agitation) when they wake up from anesthesia. It may help children recover more calmly after adenotonsillectomy.
Tanta, El-GharbiaAges 3–7 - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT07695246Recruiting
Sleep therapy with melatonin for older adults with insomnia
This study tests whether adding a melatonin supplement to a type of talk therapy for insomnia (called CBT-I) helps older adults sleep better. It aims to improve sleep quality and reduce insomnia symptoms.
Hong KongAges 60 years+ - NCT05541276RecruitingPhase 3
Melatonin to prevent waking confusion in young children after surgery
This study tests whether giving melatonin before surgery can help prevent agitation and confusion in young children after they wake up from anesthesia. Participation may help your child have a smoother recovery after their procedure.
Copenhagen, Capital RegionAges 1–6 - NCT06826755Recruiting
Melatonin for heart health in midlife women
This study tests whether melatonin can help improve heart health in midlife women with high blood pressure. It involves taking a melatonin pill or placebo for several weeks and checking blood pressure and other health markers.
Rochester, MinnesotaAges 40–55 - NCT06372561Recruiting
Melatonin vs MTA for treating tooth nerve in children
This trial compares two materials—melatonin and MTA (a commonly used dental material)—for treating the nerve of a child's permanent back tooth that has a cavity but isn't infected. The goal is to see which material works better to keep the tooth healthy.
IsmailiaAges 6–8 - NCT05358834Recruiting
Melatonin study to change uterine contractions near delivery
This study tests whether taking melatonin affects uterine contractions (how strongly and how often the uterus tightens) in pregnant people close to delivery. It may help researchers understand whether melatonin can influence labor-related processes and timing.
Boston, MassachusettsAges 18–35 - NCT06696378Recruiting
Melatonin, exercise, and breast cancer wellness study
This study tests if taking melatonin and doing a supervised exercise program together can improve health and well-being in women who had breast cancer 5 or more years ago and have gone through menopause. It aims to find a safe, natural way to feel better after treatment.
Soria, SoriaAges 60–80 - NCT07307677Recruiting
Melatonin and metformin for PCOS with insulin resistance
This study tests if adding melatonin to metformin can improve insulin resistance and other health markers in women with PCOS who have insulin resistance. It compares the combination to metformin alone.
Dhaka, ShahbagAges 18–35 - NCT06859957RecruitingPhase 3
Melatonin for chronic low back pain
This trial tests if melatonin can help reduce chronic low back pain. If you have had low back pain for at least 3 months that limits your daily activities, this study might be for you.
RotterdamAges 18–65 - NCT06546774Recruiting
Melatonin for better IVF results in women 35-45
This study tests whether taking melatonin (a natural sleep hormone) as a supplement can improve the health of cells surrounding your eggs (cumulus cells) and possibly lead to more successful IVF. It is for women aged 35 to 45 planning an IVF cycle.
Kaohsiung CityAges 35–45 - NCT07610876Recruiting
Dentin Graft With Melatonin for Tooth Implant Success
This study tests whether a special graft made from your own tooth material, with or without melatonin (an antioxidant), helps new dental implants integrate better into bone after tooth extraction. The goal is to improve how well implants take hold and function.
IsmailiaAges 20 years+ - NCT07737665RecruitingPhase 4
Melatonin for better sleep in IBD patients in remission
This study tests whether melatonin (a natural sleep hormone) can improve sleep quality in people with inflammatory bowel disease (IBD) whose disease is quiet (in remission). If you have IBD and trouble sleeping, you may be able to join.
Bangkok Noi, BangkokAges 18 years+ - NCT07743255Enrolling by invitation
Preventing migraines in children with melatonin and propranolol
This study tests whether two common medicines, melatonin and propranolol, can help prevent migraines in children. If your child has frequent, disabling migraines, this treatment might reduce how often they occur and improve daily life.
Multan, Punjab ProvinceAges 5–15 - NCT07046429Recruiting
Melatonin for sleep and brain health in cirrhosis
This study tests whether melatonin (a natural sleep hormone) can improve sleep and thinking abilities in people with cirrhosis and liver-related brain fog. It aims to see if better sleep leads to clearer thinking.
New York, New YorkAges 18 years+ - NCT07036796RecruitingPhase 2
Melatonin for diabetic nerve pain
This trial tests whether melatonin can help relieve pain and discomfort from diabetic peripheral neuropathy (nerve damage caused by diabetes). If you have type 2 diabetes with nerve pain and are on stable diabetes medications, you may be eligible.
CairoAges 40–75 - NCT07375342Recruiting
Melatonin for calming children after tonsil removal
This trial tests whether giving melatonin before surgery can help children be less agitated and confused when waking up from anesthesia after tonsil removal. If it works, it could make the recovery smoother for both children and parents.
BanhāAges 4–10 - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85
What Melatonin is being studied for
Conditions with recruiting Melatonin studies.
Common questions
- Are there clinical trials studying Melatonin?
- Yes. Clin2 currently lists 67 recruiting studies that include Melatonin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Melatonin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Melatonin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Melatonin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.