Treatment
Melatonin clinical trials
We’re tracking 64 recruiting studies that include Melatonin, each written for real people, not researchers, below.
Recruiting studies
- NCT07120880RecruitingPhase 3
Light therapy timing for depression with insomnia
This trial tests whether giving light therapy at a specific time of day can improve both depression and sleep problems. It is for adults with major depression and insomnia who are not currently on antidepressants.
ParisAges 18–65 - NCT06489327Recruiting
Melatonin before surgery for children
This trial tests two different doses of oral melatonin (a natural sleep hormone) given to children before surgery to help them relax. It may help your child feel calmer before their procedure.
Cairo, Cairo GovernorateAges 4–10 - NCT07345715Recruiting
Melatonin vs. dexmedetomidine for preventing agitation after tonsil surgery in children
This study tests whether giving children either oral melatonin or a nebulized sedative (dexmedetomidine) before surgery can reduce confusion and restlessness (emergence agitation) when they wake up from anesthesia. It may help children recover more calmly after adenotonsillectomy.
Tanta, El-GharbiaAges 3–7 - NCT07344467Recruiting
Melatonin vs. Pregabalin for pain and anxiety after spine surgery
This trial compares two medications—melatonin and pregabalin—to see which works better at reducing pain and anxiety after spine surgery. It aims to find a safer, effective option for recovery.
Tanta, El-GharbiaAges 21–60 - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT06802913RecruitingEarly Phase 1
Inhaled melatonin for sleep problems in older adults
This trial tests a new inhaled form of melatonin to help adults aged 55 and older with insomnia fall asleep faster. It compares the inhaled melatonin to a placebo to see if it improves sleep and is safe.
Macquarie Park, New South WalesAges 55 years+ - NCT06768580Recruiting
Melatonin or lidocaine to prevent confusion after hip replacement
This trial tests if giving either oral melatonin or lidocaine during surgery can reduce the chance of confusion (delirium) in older adults after total hip replacement. It compares these two approaches to standard care.
Tanta, El-GharbiaAges 65 years+ - NCT05651347RecruitingPhase 3
Melatonin in pregnancy to protect babies with slow growth
This trial studies whether taking melatonin during pregnancy can help protect the baby’s brain and organs in cases of poor fetal growth. It focuses on pregnancies at a specific gestational age with signs that the placenta may not be working well.
Camperdown, New South WalesAges 18 years+ - NCT05541276RecruitingPhase 3
Melatonin to prevent waking confusion in young children after surgery
This study tests whether giving melatonin before surgery can help prevent agitation and confusion in young children after they wake up from anesthesia. Participation may help your child have a smoother recovery after their procedure.
Copenhagen, Capital RegionAges 1–6 - NCT05502900RecruitingPhase 3
Melatonin after eye melanoma to lower spread risk
This Phase 3 study tests whether taking melatonin after treatment for uveal melanoma can reduce the chance that the cancer returns or spreads to other parts of the body. It is aimed at people with higher-risk eye melanoma features.
Stockholm, Stockholm CountyAges 18 years+ - NCT05084196RecruitingPhase 3
Melatonin to help prevent kidney damage from vancomycin
This Phase 3 study tests whether melatonin can help protect the kidneys in people who are starting or continuing vancomycin, an antibiotic that can sometimes affect kidney function. If you qualify, you would take melatonin as an added prevention step while you’re on vancomycin.
New Brunswick, New JerseyAges 18–75 - NCT05358834Recruiting
Melatonin study to change uterine contractions near delivery
This study tests whether taking melatonin affects uterine contractions (how strongly and how often the uterus tightens) in pregnant people close to delivery. It may help researchers understand whether melatonin can influence labor-related processes and timing.
Boston, MassachusettsAges 18–35 - NCT05247125RecruitingPhase 4
Testing light or melatonin to help brain recovery after stroke
This study looks at whether changing your sleep timing using light therapy or melatonin can improve “brain rewiring” after an ischemic stroke. It mainly focuses on people who arrive very soon after stroke symptoms and who also meet specific safety and sleep/medication requirements.
Saint PetersburgAges 18–80 - NCT07036367RecruitingPhase 4
Melatonin before cataract surgery for older adults
This trial is testing whether a melatonin tablet placed under the tongue before surgery can help older adults feel calmer and more comfortable during cataract surgery. Melatonin is a natural sleep hormone that may reduce anxiety without the side effects of common sedatives.
Cairo, EgyptAges 60 years+ - NCT07307677Recruiting
Melatonin and metformin for PCOS with insulin resistance
This study tests if adding melatonin to metformin can improve insulin resistance and other health markers in women with PCOS who have insulin resistance. It compares the combination to metformin alone.
Dhaka, ShahbagAges 18–35 - NCT04588233Recruiting
Melatonin study for teens with sleep trouble
This study tests whether melatonin can help teens (ages 13–17) who have trouble sleeping. You may be able to join if you’ve never taken melatonin before and your sleep issue seems to be behavior-related rather than caused by another medical sleep problem.
Loma Linda, CaliforniaAges 13–17 - NCT04547439RecruitingPhase 2
Melatonin for diabetic eye disease and better sleep
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
Chicago, IllinoisAges 40–65 - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85 - NCT02621944RecruitingEarly Phase 1
Melatonin for newborns with brain injury after oxygen problems
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
Gainesville, FloridaAges Up to 6 hours - NCT06768749Recruiting
Melatonin lotion for better sleep and mood
This trial tests whether using a scented melatonin lotion before bed can improve sleep and reduce anxiety or depression symptoms. It may be a good fit if you have mild sleep problems and some mood symptoms but are not currently taking medication for them.
Redlands, CaliforniaAges 18–21 - NCT07472075RecruitingPhase 2
Melatonin vs placebo for bipolar disorder
This trial tests whether taking melatonin (a natural sleep hormone) helps stabilize mood in people with bipolar disorder compared to a placebo (a pill with no active ingredient). It may help improve sleep and mood stability.
FrederiksbergAges 18–70 - NCT06093477Recruiting
Melatonin and recovery for teens after surgery
This study tests whether taking melatonin (a natural sleep hormone) after a major bone or joint surgery helps teens recover better. If you are 12-18 and having a surgery like scoliosis repair, you may be able to join.
Palo Alto, CaliforniaAges 12–18 - NCT05713877RecruitingPhase 2
Melatonin to treat confusion in ICU patients
This Phase 2 trial tests whether melatonin can reduce delirium, a sudden confusion that can happen in the ICU. If you qualify, you may be given melatonin to see if it improves alertness and comfort during an expected longer ICU stay.
Montreal, QuebecAges 18 years+ - NCT07036796RecruitingPhase 2
Melatonin for diabetic nerve pain
This trial tests whether melatonin can help relieve pain and discomfort from diabetic peripheral neuropathy (nerve damage caused by diabetes). If you have type 2 diabetes with nerve pain and are on stable diabetes medications, you may be eligible.
CairoAges 40–75
What Melatonin is being studied for
Conditions with recruiting Melatonin studies.
Common questions
- Are there clinical trials studying Melatonin?
- Yes. Clin2 currently lists 64 recruiting studies that include Melatonin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Melatonin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Melatonin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Melatonin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.