FAPI PET scan to predict relapse in IgG4-RD
Part of Immune system & allergy clinical trials.
This study tests whether a special PET scan (FAPI PET/CT) can detect tiny signs of disease activity (MRD) in people with stable IgG4-RD, and whether it helps predict who might relapse.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with IgG4-RD using the 2019 ACR/EULAR criteria.
- Your disease has been stable and in complete remission for at least 1 year.
- You have been on low-dose steroids (prednisone 7.5 mg/day or less) for 6 months or more, or you take one specific immunosuppressant at a low dose (mycophenolate ≤1g/day, leflunomide ≤20mg/day, methotrexate ≤15mg/week, azathioprine ≤100mg/day, or iguratimod ≤25mg twice daily).
- You do not have active infections (like HIV, hepatitis B/C, TB), cancer, pregnancy, or severe irreversible organ damage.
- You are not currently in a disease flare (active stage) and have not relapsed within the last year when reducing hormones.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study uses a special PET scan (FAPI PET) to look at inflammation in people with Sjögren's syndrome. It helps doctors understand how active the disease is. You may join if you have Sjögren's syndrome or a solid tumor that needs this scan, and you are not on certain medications.
This trial tests a short course of steroids combined with mycophenolate mofetil (MMF) for people with active IgG4-related disease who have not been treated before or whose disease came back after stopping treatment. The goal is to see if this combination helps control the disease better.
This trial tests a new imaging scan (SPECT) that uses a special tracer (99mTc-TCR-FAPI) to see inflammation in the joints of people with rheumatoid arthritis. It aims to help doctors better understand and track disease activity.
This study tests a new type of PET scan (a medical imaging test) that may better detect inflammation in the body compared to the standard scan currently used. Researchers will compare the two scans in patients with fever of unknown origin, IgG4-related disease, or inflammatory back pain.
This trial uses a special PET/CT scan with a tracer called 68Ga-FAPI-46 to see if it can better detect inflammation and scarring (fibrosis) in people with chronic diseases like scleroderma, pulmonary fibrosis, or rheumatoid arthritis. The goal is to improve diagnosis and monitoring.
This trial tests a new type of PET scan to see if it can accurately spot inflamed or damaged areas in the intestines of people with inflammatory bowel disease (IBD). If it works, it could help doctors track disease activity without relying only on invasive tests.
Hear when a new IgG4-Related Diseases trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.