Surgery with or without radiation for prostate cancer
Part of Cancer, Kidney & urinary clinical trials.
This trial compares radical prostatectomy (surgery to remove the prostate) alone versus surgery plus pelvic lymph node removal, with or without additional radiation, for men with intermediate- or high-risk prostate cancer that has not spread. It aims to see which approach is more effective and safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a man aged 18 to 80 years.
- You have been diagnosed with intermediate- or high-risk prostate cancer that is still confined to the prostate (no spread to lymph nodes or other areas).
- Your cancer risk score on the Briganti nomogram is 7% or higher.
- You have not had any prior treatment for prostate cancer (like radiation, chemotherapy, or hormone therapy).
- You are medically able to undergo surgery (prostatectomy) and possibly radiation therapy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether using a combined PSMA-PET/MRI and ultrasound navigation system during robot-assisted prostate removal can help the surgeon remove the cancer more completely while preserving surrounding tissue. It is for patients with early-stage prostate cancer that is just starting to spread outside the prostate.
This trial compares two standard treatment options—radiation or surgery—for people with high-risk prostate cancer that has not spread. The goal is to see which approach works better for long-term cancer control and side effects.
This study tests two different radiation approaches for men with prostate cancer that has returned after surgery and is found only in the pelvic lymph nodes. The goal is to see if one schedule is better at controlling the disease while limiting side effects.
This trial looks at radiation therapy given after prostate surgery (or if needed later) for prostate cancer where lymph nodes were not involved. It may help patients whose PSA rises or who need additional treatment to reduce the chance the cancer comes back.
This trial is testing whether a special scan (PSMA PET/CT) before surgery can help doctors decide if you need to remove lymph nodes. It is for men with high-risk prostate cancer who are already planning to have robot-assisted prostate removal.
This study tests whether adding a type of high-precision radiation (MDRT) to standard hormone therapy works better for men with prostate cancer that has spread to just a few places. It is for patients who are newly diagnosed and on long-term hormone therapy.
Hear when a new Prostate cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.