Nintedanib to improve pregnancy in adenomyosis
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This study tests whether taking a medication called nintedanib before embryo transfer improves pregnancy chances in women with adenomyosis. Nintedanib may help by reducing inflammation and abnormal blood vessels in the uterus linked to adenomyosis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 20 and 38 years old
- You have been diagnosed with infertility (primary or secondary)
- You have at least one frozen, high-quality embryo (grade 4BB or better) stored
- You have been diagnosed with adenomyosis within the past 3 months (confirmed by MRI or vaginal ultrasound)
- Your BMI is between 18 and 27
- You do not have other significant uterine problems (like fibroids, polyps, or hydrosalpinx) or other major health conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving a hormone-lowering drug for a longer time before frozen embryo transfer, plus adding a hormone pill (letrozole), improves success for people with adenomyosis. It aims to help those with this womb condition have a better chance of a successful pregnancy.
This study tests whether adding a medicine called letrozole to standard hormone therapy improves the chances of pregnancy in women with adenomyosis who are doing IVF. Adenomyosis is a condition where tissue that normally lines the womb grows into the womb muscle, which can affect fertility.
This study follows people with adenomyosis to see which treatments work best for pain and heavy bleeding. It may help doctors find better ways to manage symptoms.
This study tests whether using a hormone medication (GnRH agonist) before a frozen embryo transfer helps women with adenomyosis. If you have adenomyosis and are planning a frozen embryo transfer, this trial will help compare results with or without the pre-treatment.
This study tests whether frozen embryo transfer (placing a previously frozen embryo in the uterus) is effective for women with adenomyosis (a condition where uterine tissue grows into the uterine wall). It may help improve pregnancy chances for women with this condition.
This study tests if treating immune system factors can help women with adenomyosis who are having trouble getting pregnant. It aims to see if addressing these immune aspects improves pregnancy chances.
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