Hormone treatment before frozen embryo transfer for adenomyosis
Part of Women’s health & pregnancy clinical trials.
This trial tests whether giving a hormone-lowering drug for a longer time before frozen embryo transfer, plus adding a hormone pill (letrozole), improves success for people with adenomyosis. It aims to help those with this womb condition have a better chance of a successful pregnancy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have adenomyosis, confirmed by a vaginal ultrasound.
- You are between 20 and 38 years old.
- You are planning a frozen transfer of a single embryo (day 5 or day 6).
- You have had no more than 2 previous embryo transfer attempts.
- You do not have certain other conditions like lupus, large fibroids (5 cm or more), or a history of specific womb/cervix surgeries.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether adding a medicine called letrozole to standard hormone therapy improves the chances of pregnancy in women with adenomyosis who are doing IVF. Adenomyosis is a condition where tissue that normally lines the womb grows into the womb muscle, which can affect fertility.
This study tests whether taking a medication called nintedanib before embryo transfer improves pregnancy chances in women with adenomyosis. Nintedanib may help by reducing inflammation and abnormal blood vessels in the uterus linked to adenomyosis.
This trial explores how natural uterine contractions affect pregnancy success in women using hormone therapy for frozen embryo transfer. It may help doctors understand if uterine activity influences implantation.
This study looks at how different ways of preparing the uterus for a frozen embryo transfer affect the natural wavelike movements of the womb lining (endometrial peristalsis). It may help doctors choose the best protocol for you.
This study tests whether using a hormone medication (GnRH agonist) before a frozen embryo transfer helps women with adenomyosis. If you have adenomyosis and are planning a frozen embryo transfer, this trial will help compare results with or without the pre-treatment.
This study tests whether frozen embryo transfer (placing a previously frozen embryo in the uterus) is effective for women with adenomyosis (a condition where uterine tissue grows into the uterine wall). It may help improve pregnancy chances for women with this condition.
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