Chemotherapy plus radiation before surgery for advanced breast cancer
Part of Cancer, Skin clinical trials.
This trial tests adding radiation therapy to chemotherapy before surgery for people with locally advanced breast cancer that did not shrink enough with chemo alone. It may help improve outcomes for those with luminal (HER2-negative) or triple-negative types.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have invasive breast cancer confirmed by biopsy.
- Your tumor is large or has spread to nearby lymph nodes (stage T3-4, N1-2) but not to other organs.
- Your cancer type is called luminal (HER2-negative) or triple-negative.
- Your tumor did not shrink by half or more after 2 rounds of chemotherapy.
- You are generally in good health with a performance status score above 70.
- You can have an MRI scan and are able to attend follow-up visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving radiation therapy along with other cancer treatments before surgery can help early-stage breast cancer that has spread to the lymph nodes. The goal is to see if this approach is safe and works better than standard treatment.
This trial compares two treatments for locally advanced breast cancer: chemotherapy before surgery plus radiation, versus chemotherapy before surgery alone. The goal is to see which approach works better for this specific type of cancer.
This trial tests giving immunotherapy combined with a precise, high-dose radiation boost before surgery for HER2-negative breast cancer. The goal is to see if this approach can improve outcomes, especially for cancers that are more advanced or have spread to a few other spots in the body.
This Phase 3 study tests a specific plan that combines chemotherapy (and sometimes targeted medicines) with radiation before surgery for one breast. It may help shrink breast cancer and improve treatment timing, based on how well tumors respond.
This trial tests a new approach for breast cancer that combines a short course of focused radiation (SBRT) with an injection of the immunotherapy drug pembrolizumab directly into the tumor, followed by standard chemotherapy before surgery. The goal is to see if this combination helps shrink the tumor more effectively before surgery.
This trial tests a treatment given before breast surgery to shrink breast cancer and improve outcomes based on your tumor type. Your eligibility depends on tumor size/stage, hormone and HER2 markers, and overall health checks.
Hear when a new Breast cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.