Chemotherapy plus radiation before breast cancer surgery
Part of Cancer, Skin clinical trials.
This study tests combining chemotherapy before surgery with radiation therapy before surgery for locally advanced breast cancer. The goal is to see if this approach can improve outcomes, especially for patients whose tumors didn't shrink enough with initial chemo.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have invasive breast cancer that is either hormone-receptor-positive (Luminal) or triple-negative, and it has not spread to distant organs.
- Your tumor is large (T3-T4) or has spread to nearby lymph nodes (N1-N2), and it did not shrink by more than half after two cycles of chemo.
- You are generally in good health (able to care for yourself) and your organs are working well enough for treatment.
- You can have an MRI scan (for imaging).
- You are not pregnant, and you do not have diabetes, inflammatory breast cancer, active connective tissue disease, or very large breasts (over 600ml) with a BMI over 30.
- You haven't had radiation to your chest before, and you aren't taking immunotherapy drugs like PD-1/PD-L1.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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