Combination therapy for fibromyalgia pain
Treatments studied
Part of Bones, joints & muscles, Brain & nervous system, Pain clinical trials.
This study tests whether combining two medications, pregabalin (often used for nerve pain) and desvenlafaxine (an antidepressant that can also help with pain), is safe and effective for people with fibromyalgia who still have moderate to severe pain after trying non-drug treatments like exercise or therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with fibromyalgia using the 2016 updated criteria.
- Your pain level is moderate to severe (at least a 4 on a 0-to-10 pain scale).
- You have not already tried prescription medications like pregabalin or certain antidepressants for fibromyalgia.
- Your liver and kidney function tests must be within safe limits (this will be checked with a blood test).
- You do not have other conditions causing pain (like arthritis or injury) or a history of seizures or untreated depression.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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