Cancer DNA test to guide chemo after rectal cancer surgery
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether checking for tumor DNA in your blood after surgery can help decide if you need additional chemotherapy. If the test finds cancer DNA, you may get chemo to lower the risk of the cancer coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had surgery for rectal cancer and a blood test after surgery shows signs of cancer DNA.
- You are 18 years or older.
- You are well enough to be up and about (World Health Organization score 0 or 1).
- You are able to read and understand Dutch.
- You are eligible to receive chemotherapy with CAPOX or FOLFOX, as decided by your doctor.
- You have not been treated for another cancer in the last 5 years (except for very early skin or cervical cancer).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether a blood test that finds tumor DNA can help doctors choose the best treatment for rectal cancer, possibly allowing some patients to avoid surgery. It tests different chemotherapy and radiation combinations to see if the cancer disappears completely.
This trial is looking at whether a simple blood test (ctDNA monitoring) can help predict how well total neoadjuvant therapy (chemo and radiation before surgery) works for rectal cancer. It may help doctors tailor treatment to your specific needs.
This study looks at how rectal cancer responds to the usual chemotherapy and radiation given before surgery. It aims to learn if certain molecular features of your tumor can predict how well it responds to treatment.
This trial tests whether some people with locally advanced rectal cancer can safely avoid surgery after chemoradiotherapy. If the tumor disappears, patients may be monitored closely instead of having an operation, which could help preserve the anus.
This trial is for people with stage II colon cancer who are not currently getting chemotherapy. It uses a blood test to look for tumor DNA, so doctors can decide if chemotherapy might help prevent the cancer from coming back.
This trial uses a special DNA blood test (circulating tumor DNA) to help guide chemotherapy and radiation before surgery for locally advanced rectal cancer. It aims to improve outcomes by tailoring treatment based on the DNA signals from the tumor.
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