Seeing tumor markers in esophageal cancer with special imaging
Part of Cancer, Digestive system clinical trials.
This study will test whether special imaging dyes can help doctors see a protein called PD-L1 on esophageal cancer tumors. This might help guide treatment by showing whether immunotherapy drugs are likely to work.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have locally advanced esophageal cancer (cancer in the esophagus that has grown deeply or spread to nearby lymph nodes, but not to distant organs).
- Your doctor plans to treat you with chemotherapy and/or radiation before surgery, or with radiation and chemotherapy as the main treatment (without surgery).
- You are 18 years old or older.
- You do not have an autoimmune disease that you are currently receiving treatment for.
- You are not pregnant or breastfeeding, and if you could become pregnant, you have a negative pregnancy test.
- You have not had an allergic reaction to drugs like durvalumab or nivolumab in the past.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether special PET/CT scans can help predict how well immunotherapy works before surgery for esophageal cancer. It aims to improve treatment planning by identifying patients who may need additional therapy.
This trial looks at whether certain cells in your lymph nodes (small immune glands) can predict how well PD-1 inhibitors (a type of immunotherapy) will work for your advanced or recurrent esophageal cancer. It aims to find a way to tailor treatment to each person.
This trial is testing a way to predict whether immunotherapy (a treatment that helps your immune system fight cancer) will completely eliminate esophageal cancer before surgery. By examining lymph nodes, they hope to tailor treatment more personally.
This trial tests whether a personalized treatment plan, chosen using a lab-grown model of your tumor, works better than standard therapy for esophageal cancer that can be surgically removed. It aims to find the most effective drugs for you before surgery.
This trial tests a treatment for locally advanced esophageal cancer. You'll receive chemoradiation (chemo plus radiation) followed by a maintenance drug (a PD-1 inhibitor) to help prevent the cancer from coming back.
This study tests a new treatment for people with locally advanced esophageal cancer that did not respond to initial chemotherapy and immunotherapy. The goal is to see if the study drug can shrink or control the cancer when surgery is not an option.
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