Clin2
NCT07203391Worth exploringRecruiting

Tebentafusp and roginolisib for uveal melanoma

Uveal Melanoma, Metastatic

Treatments studied

Part of Cancer, Eyes & vision clinical trials.

This trial tests a combination of two drugs, tebentafusp and roginolisib, for people with uveal melanoma that has spread or can't be removed. It aims to improve how long the immune system stays active against the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
8 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have uveal melanoma that has spread or cannot be surgically removed.
  • You have a specific immune system marker called HLA-A*02:01.
  • You are able to take care of yourself (ECOG score 0 or 1).
  • You are currently receiving tebentafusp as your first treatment for advanced uveal melanoma.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04855435Recruiting· Phase 1
Study drug for advanced melanoma and other solid tumors

This Phase 1 trial studies a new experimental immunotherapy (MBS8) for people with advanced solid tumors, focusing first on safety and early signs of benefit. Depending on your cancer type and past treatments, you may receive MBS8 alone or combined with pembrolizumab.

Herlev
NCT07063875Recruiting· Phase 1/Phase 2
Adding IL-2 to tebentafusp for advanced eye cancer

This trial tests if adding another drug called IL-2 to tebentafusp can help stop cancer from growing in people with advanced melanoma that started in the eye (uveal melanoma). It is for those whose cancer got worse while on tebentafusp alone.

Sydney, New South Wales
NCT06246149Recruiting· Phase 3
Tebentafusp after treatment for high-risk eye melanoma

This trial tests a new drug called tebentafusp given after standard treatment (surgery or radiation) for high-risk uveal melanoma that hasn't spread. The goal is to see if it helps prevent the cancer from coming back.

Lake Success, New York
NCT06070012Recruiting· Phase 2
Tebentafusp for untreated metastatic uveal melanoma

This trial tests a new drug called tebentafusp for people with uveal melanoma that has spread to other parts of the body and who have not yet received any treatment for the metastatic disease. It requires a specific genetic marker (HLA-A*0201) and focuses on whether the drug can shrink or slow the growth of tumors.

Aurora, Colorado
NCT06626516Recruiting· Phase 1/Phase 2
Tebentafusp and LDT for metastatic uveal melanoma

This trial tests a combination of two drugs (tebentafusp and a liver-directed treatment called LDT) for people with uveal melanoma that has spread to the liver. The goal is to see if this combination helps shrink tumors and improve outcomes.

Philadelphia, Pennsylvania
NCT06414590Recruiting· Phase 2
Tebentafusp before surgery for eye melanoma

This trial tests a drug called Tebentafusp for a type of eye melanoma (uveal melanoma) that is too large to be removed without taking out the whole eye. The goal is to see if the drug can shrink the tumor before deciding on surgery.

Philadelphia, Pennsylvania

Hear when a new Uveal Melanoma, Metastatic trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.