Clin2
NCT07205185Possibly a fitNot yet recruiting

New drug combination with radiation for advanced soft tissue sarcoma

Soft Tissue Sarcoma (STS)

Part of Cancer clinical trials.

This trial is testing a new combination of four treatments (an experimental drug, two chemo-like drugs, and radiation) for advanced soft tissue sarcoma that hasn't responded to earlier treatments. The goal is to see if this combination can help shrink or slow the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
46 people
Ages
14 years to 75 years
Study type
Interventional

Who can take part

  • You must be 14 to 75 years old.
  • You must have advanced soft tissue sarcoma (a type of cancer in the body's soft tissues, like muscle, fat, or blood vessels).
  • Your sarcoma must have gotten worse after at least one prior treatment (like chemotherapy).
  • You should be in fairly good overall health – able to do most daily activities without needing to rest in bed for more than half the day.
  • Your liver, kidneys, and blood counts must be within certain limits, and you must not have serious heart or breathing problems, or active hepatitis B or C, or HIV.
  • You must not have had certain other sarcoma types like Ewing sarcoma, rhabdomyosarcoma, or GIST.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06699576Not yet recruiting· Phase 1
Combination treatment for bone and soft tissue sarcoma

This trial tests a new drug, HS-20093, combined with other treatments for people with advanced bone or soft tissue sarcoma. The goal is to see if these combinations can shrink tumors or slow their growth.

NCT07612098Not yet recruiting· Phase 2
Radiation and drug combo before surgery for soft tissue sarcoma

This trial tests a combination of radiation therapy and two drugs (anlotinib and penpulimab) given before surgery for soft tissue sarcoma. The goal is to see if this approach can shrink tumors and improve outcomes.

Beijing, Beijing Municipality
NCT07342322Not yet recruiting· Phase 2
Radiation and praG for advanced soft tissue sarcoma

This trial tests a new way of giving radiation therapy (called spatially fractionated radiotherapy) combined with a treatment strategy called PraG (pembrolizumab and granulocyte-macrophage colony-stimulating factor) for people with soft tissue sarcoma that cannot be removed or has spread. The goal is to see if the combination can help shrink or control the cancer.

Nanning, Guangxi
NCT07460986Recruiting· Phase 1/Phase 2
Bexmarilimab plus doxorubicin for advanced soft-tissue sarcoma

This trial tests a new drug called bexmarilimab combined with doxorubicin for people with soft-tissue sarcoma that has spread to other parts of the body. The goal is to see if the combination is safe and works better than doxorubicin alone.

Badalona
NCT07650838Not yet recruiting· Phase 2
A new combination therapy for advanced soft tissue sarcoma

This trial tests a new combination therapy: an injected virus (OVV-01) alongside an immunotherapy drug (AK112) for people with advanced soft tissue sarcoma that hasn't responded to usual treatments. The aim is to see if this approach can help shrink tumors or slow their growth.

NCT07156643Not yet recruiting· Phase 2
Combination treatment for advanced soft tissue sarcoma

This study tests a combination of two drugs (anlotinib and bempegaldesleukin) plus standard chemotherapy and radiation for people with advanced soft tissue sarcoma that has spread or can't be removed. The goal is to see if this combination helps shrink tumors and control the cancer.

Nanjing

Hear when a new Soft Tissue Sarcoma (STS) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.