Clin2
NCT07221617Possibly a fitRecruiting

Methadone for pain after heart surgery

Pain, PostoperativeAnesthesiaCardiac Surgery

Treatments studied

Part of Pain clinical trials.

This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
100 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are scheduled for elective heart surgery (not an emergency).
  • You do not take prescription opioids for chronic pain at home.
  • You do not have a history of opioid use disorder or take medication for it.
  • You do not have a very long QT interval on your heart tracing (over 500 ms).
  • You do not have advanced kidney disease (eGFR below 30) or liver cirrhosis.
  • You are not pregnant at the time of surgery.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06728371Recruiting· Phase 3
IV methadone for pain after heart surgery

This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.

Hong Kong
NCT07517679Recruiting· Phase 4
Methadone for Pain After Spine Surgery

This study tests whether methadone, an opioid medication, can safely manage pain after elective spine surgery. Researchers want to see if it works well and is safe for patients staying overnight in the hospital after their procedure.

Lexington, Kentucky
NCT06387303Recruiting· Early Phase 1
Comparing IV Methadone vs Spinal Morphine for Pain After Abdominal Surgery

This study compares two strong painkillers—methadone given through an IV versus morphine injected into the spine—to see which provides better pain relief and recovery after major abdominal surgery. It may help you if you're having open surgery and want less pain afterward.

Charlottesville, Virginia
NCT07537608Not yet recruiting
Understanding How Parents and Doctors View Methadone for Surgery

This study asks caregivers and medical staff about their views on methadone use during children's outpatient surgery. Your feedback helps researchers understand concerns and improve communication around pain management.

NCT07565870Not yet recruiting· Phase 3
Methadone for Better Pain Control After Surgery

This trial tests whether methadone—a strong pain medication—helps manage pain better after intermediate-complexity surgery. If it works, it could reduce pain and the need for other opioids after your operation.

Irvine, California
NCT05831345Recruiting· Phase 3
Methadone during surgery to prevent post-surgery pain

This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.

Brussels

Hear when a new Cardiac Surgery trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.