Methadone during surgery to prevent post-surgery pain
Treatments studied
Part of Pain clinical trials.
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 80 years old
- You are having planned hip or knee replacement surgery (partial or total)
- Your overall health is in the mild-to-moderate range (ASA 1 to 3)
- You do not have kidney problems before surgery (based on blood tests and kidney function)
- You do not have serious liver problems or known heart failure
- You have no opioid-related red flags (no opioid use before surgery or past opioid abuse), and no allergy to methadone or sufentanil
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
This trial tests whether methadone—a strong pain medication—helps manage pain better after intermediate-complexity surgery. If it works, it could reduce pain and the need for other opioids after your operation.
This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.
This trial tests if taking methadone pills after arthroscopic knee or hip surgery can help manage pain effectively. It's for people who are otherwise healthy and ready for surgery.
This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.
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