Studying immune cells in children's solid tumors

This study collects and studies tissue or bone marrow samples from certain childhood tumors. The goal is to learn what’s going on inside the cancer (using molecular testing) to better understand the disease and how it may respond to treatment.

This study collects immune and tumor-related samples to learn what predicts response to adoptive cell therapy (a treatment using immune cells). If you (or your child) are eligible, you may help researchers understand who benefits and why.

This trial uses special lab models (“immune organoids”) to study certain cancers in children and young people. It may help researchers learn what those cancers do and improve future treatment ideas.

This study is looking at a specific type of immune cell (called TLR4+ cells) in the blood of people with solid tumors. By studying these cells, researchers hope to learn more about how the immune system reacts to cancer and to treatments.

This trial uses a patient's own tumor-fighting immune cells (TILs) to treat high-risk solid tumors outside the brain in children and young adults. It has two parts: first, a tumor sample is collected during surgery, and then the immune cells are grown in a lab and given back to the patient to attack the cancer.

This trial tests a modified version of your own immune cells (made from your blood) to help treat advanced cancers that are no longer responding to standard treatment. It’s designed mainly to see if the approach is safe and how well it may work for people whose disease has progressed.