Ketamine therapy for alcohol use and depression
Treatments studied
Part of Mental health clinical trials.
This study is testing whether ketamine, given alongside therapy, can help people who have both alcohol use disorder and depression. The goal is to see if this combination reduces drinking and improves mood.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have both alcohol use disorder (AUD) and major depression (MDD) as diagnosed by a doctor.
- You should be 18 to 70 years old and motivated to cut down or stop drinking.
- In the past month, you need to have drunk at least 21 standard drinks a week or had at least 2 heavy drinking days (4-5+ drinks per occasion).
- You must have stable housing and be able to read, understand, and speak English well enough to complete interviews.
- You cannot be pregnant or breastfeeding, and you must not have taken ketamine in the past 4 weeks.
- You need to be free of serious health problems like heart disease, severe high blood pressure, seizures, or severe liver disease, and no active psychosis or recent suicide attempt.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study combines behavioral activation therapy (a type of counseling that helps you re-engage in positive activities) with ketamine infusions to treat depression that hasn't improved with standard antidepressants. The goal is to see if adding this therapy makes ketamine work better and last longer.
This study tests whether ketamine can help reduce suicidal thoughts in people with depression. It also looks at how ketamine affects a brain receptor that may be linked to mood and stress, to learn why it might help.
This study tests whether combining ketamine with a brain-training technique called neurofeedback can help people reduce or stop drinking alcohol. It may offer a new treatment option for alcohol use disorder.
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Hear when a new Comorbidities and Coexisting Conditions trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.