Ozanimod vs azathioprine for steroid-dependent ulcerative colitis
Treatments studied
Part of Digestive system clinical trials.
This study tests whether ozanimod works better than azathioprine in people with ulcerative colitis who need high-dose steroids. Both groups also stay on steroids. The goal is to see if either drug helps you reduce or stop steroids while keeping symptoms under control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have ulcerative colitis.
- You need at least 30 mg of prednisone (or a similar steroid) every day to manage your condition.
- You are starting ozanimod or azathioprine medication along with your steroid, not on the same day.
- If you are in the ozanimod group, you still had noticeable symptoms (like rectal bleeding) when you started the drug.
- If you are in the azathioprine group, you must have started it after February 2019.
- You cannot have other health issues that require ongoing steroid use (except for inhalers or skin creams).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if starting with the stronger drug mirikizumab (top-down therapy) works better than the usual treatment with azathioprine for people newly diagnosed with moderate-to-severe ulcerative colitis. It aims to see which approach controls inflammation and improves symptoms faster.
This trial tests a new drug, OD-07656, followed by vedolizumab, in people with moderate to severe ulcerative colitis. It aims to see if this approach is safe and helps control symptoms when other treatments have not worked well.
Researchers want to see if taking two medications together (upadacitinib and vedolizumab) works better than taking just upadacitinib alone for people with moderate to severe ulcerative colitis. This is a real-world study, meaning it looks at patients being treated in normal medical practice.
This trial tests whether an oral medicine called ozanimod can improve ulcerative colitis (UC) in children whose disease is moderate to severe. It’s meant for kids who didn’t fully respond—or couldn’t tolerate—standard UC treatments.
This study looks at how the medicine ozanimod works in people with active ulcerative colitis. Researchers will use a special blood test to understand how the drug affects your immune system.
This trial tests if adding upadacitinib (a pill) to standard steroid treatment helps people with a severe flare of ulcerative colitis feel better faster. You may qualify if you are having frequent bloody stools and signs of serious inflammation, and you haven't tried upadacitinib before.
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