Clin2
NCT07282678Possibly a fitRecruiting

Adaptive brain stimulation for treatment-resistant depression.

Depression - Major Depressive DisorderTranscranial Alternating Current Stimulation

Part of Mental health clinical trials.

This study tests a new brain stimulation device that adjusts its signal in real time to treat depression. It's for people who haven't gotten enough help from antidepressants and are looking for a non-drug option.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
214 people
Ages
22 years and older
Study type
Interventional

Who can take part

  • You must be 22 years of age or older.
  • You are currently experiencing a major depressive episode with at least moderate symptoms.
  • You have tried at least one antidepressant but did not get enough relief or had side effects.
  • For 6 weeks before starting, you must be either not taking antidepressants, or on a steady dose of one or more antidepressants (and keep that same dose during the study).
  • You cannot have used other brain stimulation treatments like ECT or TMS in the past 6 months or ever failed those treatments.
  • You must not have had suicidal thoughts with a plan or intent, or any suicidal behavior, in the last 3 months.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07185451Recruiting
Brain stimulation for teens with depression

This trial tests if a gentle electrical brain stimulation called tACS can help teens with depression who are already on stable medication. The treatment is added to their usual medication to see if it improves mood.

Chongqing, Chongqing Municipality
NCT07185464Not yet recruiting
Brain stimulation for teens with first-time depression

This trial studies a non-drug brain stimulation technique (called tACS) that uses gentle electrical currents to help regulate mood in teenagers with first-episode depression who have not yet taken antidepressants. If effective, it could offer a drug-free option for managing depression.

Chongqing, Chongqing Municipality
NCT07611773Recruiting
Brain Stimulation for Depression Treatment Planning

This study tests whether brain scans can predict which people with depression will benefit from transcranial direct current stimulation (tDCS)—a non-invasive treatment that uses mild electrical pulses to stimulate brain areas related to mood. You would use a small home device and complete brain monitoring sessions.

Valencia
NCT07804459Not yet recruiting· Early Phase 1
Personalized brain stimulation for depression

This study uses brain imaging to guide a noninvasive treatment called transcranial magnetic stimulation (TMS) for people with depression. It aims to see if tailoring the stimulation to each person's brain can improve symptoms.

Philadelphia, Pennsylvania
NCT06891326Recruiting
Testing tACS for depression relief

This study tests if a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can safely treat depression. It uses mild electrical pulses on the scalp to help improve mood.

Shanghai
NCT07712159Not yet recruiting
Brain stimulation with alternating currents for depression

This trial tests a new kind of brain stimulation that uses special electrical currents to target areas linked to depression. It's for people who haven't gotten enough relief from standard antidepressants.

Hear when a new Depression - Major Depressive Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.