Testing purine-related compounds for PXE
Part of Blood & lymphatic, Genetic & congenital, Heart & circulation, Skin clinical trials.
This trial tests a compound that affects certain chemicals in your body (purines) to see if it helps people with pseudoxanthoma elasticum (PXE), a rare genetic condition affecting skin, eyes, and blood vessels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You must have a confirmed diagnosis of pseudoxanthoma elasticum (PXE) with a known ABCC6 gene mutation.
- You cannot be taking certain medicines like bisphosphonates, vitamin K antagonists, or supplements with calcium, phosphates, magnesium, zinc, or iron.
- You cannot take caffeine, salbutamol, or beta-blockers during the trial.
- You must not have active bone diseases (like osteoporosis), cancer, or inflammatory/autoimmune conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This study looks at whether a new way of organizing care helps patients with pseudoxanthoma elasticum (PXE). It also asks some patients about their experience with the new care setup.
This trial studies whether taking PPI-type supplements can slow or reduce unwanted calcification in people with PXE. It’s meant to help manage disease changes caused by abnormal calcium deposits, based on your medical testing.
This study looks at blood flow in a layer of the eye called the choriocapillaris in people with pseudoxanthoma elasticum (PXE). It compares these findings with healthy volunteers to understand eye changes before they become severe.
This Phase 3 study tests a medicine to help prevent abnormal calcium (called ectopic mineralization) from building up in people with pseudoxanthoma elasticum (PXE). It aims to slow or reduce new damage over time.
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