Clin2
NCT07361549Possibly a fitRecruiting

Lidocaine injection for chronic migraine pain

Refractory MigraineHeadache

Treatments studied

Part of Brain & nervous system, Pain clinical trials.

This study tests if injecting lidocaine (a numbing medicine) into an artery in the head can reduce chronic migraine pain. It may help people who have frequent migraines and are already getting a brain imaging test.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
80 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years old or older.
  • You have been diagnosed with chronic migraine.
  • You are scheduled for a brain angiogram to check for other problems.
  • You do not have other serious brain conditions (like cancer or malformed blood vessels).
  • You are not pregnant, breastfeeding, or unwilling to use birth control during the study.
  • You are not allergic to lidocaine or similar numbing medicines.
  • You are not taking certain medicines that could interact with lidocaine (your doctor will check).
  • You are not participating in another experimental treatment study.
  • You are able to follow the study plan and give written consent.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06582810Recruiting
Lidocaine for headaches after brain bleed

This study tests whether a lidocaine infusion (given through an IV) can safely reduce severe headaches after a subarachnoid hemorrhage (a type of brain bleed). You may qualify if you had a spontaneous bleed and can communicate your pain level.

Wichita, Kansas
NCT07294118Recruiting· Phase 2
Lidocaine and steroids for pain after brain bleed

This trial tests whether giving a numbing medicine (lidocaine) and steroids into the artery that covers the brain can help reduce pain after a brain bleed. It may be an option for people with a specific type of bleeding who have not had certain brain surgeries or procedures.

Galveston, Texas
NCT07764783Not yet recruiting· Phase 2
Numbing spray for ongoing migraine

This study tests whether a numbing spray applied inside the nose can relieve ongoing migraine pain. It may help people who have both migraines and sinus-like pressure or pain.

Springfield, Massachusetts
NCT07661758Recruiting· Phase 3
Lidocaine to prevent headache after C-section

This trial tests if giving lidocaine through an IV can prevent the headache that sometimes happens after spinal anesthesia during a planned C-section. If you are having a planned C-section with spinal anesthesia and meet other health requirements, this study might help reduce your risk of post-procedure headache.

Tanta, Gharbia Governorate
NCT07061847Recruiting· Phase 2
Lidocaine infusion for severe chronic migraines

This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.

Great Neck, New York
NCT06935552Not yet recruiting· Early Phase 1
Ketamine and lidocaine infusions for hard-to-treat chronic migraine

This study tests whether giving two pain-relieving medicines, ketamine and lidocaine, through an IV can help adults with chronic migraine that hasn't improved with other treatments. The goal is to see if this treatment reduces migraine pain and improves daily life.

Hear when a new Refractory Migraine trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.