Esketamine for breast cancer surgery patients with severe depression
Treatments studied
Part of Cancer, Mental health, Skin clinical trials.
This trial tests whether a medication called esketamine, given during breast cancer surgery, can help reduce feelings of depression and anxiety after the operation. It is for women who are already experiencing severe depressive symptoms before surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are scheduled to have breast cancer surgery.
- You have severe depressive symptoms, as measured by a standard questionnaire (score of 15 or higher).
- Your surgery is expected to last at least 90 minutes.
- You are not currently taking antidepressants, antipsychotics, or steroids, and you do not have a history of alcohol or drug abuse.
- You do not have serious heart, lung, liver, kidney, or blood clotting problems, and you do not have conditions like high blood pressure that is not controlled, or increased pressure in the brain or eyes.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving a medication called esketamine during breast cancer surgery can help reduce feelings of depression and anxiety after the operation. If you are having breast cancer surgery and have been feeling down, this treatment might support your emotional well-being during recovery.
This trial tests whether a medicine called esketamine, given during breast cancer surgery, can help reduce negative emotions like anxiety or depression before and after the operation. It may help you feel more emotionally stable during your treatment.
This study tests whether a ketamine nasal spray can help reduce depression and anxiety in people with advanced cancer. It also looks at how caregivers are affected. If you are living with progressive cancer and feeling down or anxious, this treatment might offer some relief.
This study tests whether adding a low dose of esketamine (a type of anesthesia) to modified electroconvulsive therapy (ECT) helps treat severe depression in teenagers. It aims to see if this combination works better and is safer than ECT alone.
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
This trial tests whether a low dose of esketamine can improve sleep quality in women with breast cancer who are receiving neoadjuvant chemotherapy. If you have trouble sleeping during treatment, this study may find a new way to help.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.