Treatment
Esketamine clinical trials
We’re tracking 56 recruiting studies that include Esketamine, each written for real people, not researchers, below.
Recruiting studies
- NCT06399185RecruitingPhase 4
Medicines for catheter discomfort after bladder or prostate surgery
This study tests whether two medicines, dexmedetomidine and esketamine, can reduce discomfort from a urinary catheter after bladder or prostate surgery. If you are having this type of surgery and need a catheter, this trial may help find a better way to manage that discomfort.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07247968RecruitingEarly Phase 1
Esketamine with ECT for severe depression in teens
This study tests whether adding a low dose of esketamine (a type of anesthesia) to modified electroconvulsive therapy (ECT) helps treat severe depression in teenagers. It aims to see if this combination works better and is safer than ECT alone.
ChongqingAges 13–17 - NCT07308756RecruitingPhase 4
Study on two drugs for better recovery after surgery
This trial tests if giving two medicines, dexmedetomidine and esketamine, during and after surgery can help you feel better and recover more comfortably. It is for adults having general anesthesia for at least one hour who will use a patient-controlled pain pump afterward.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07125573Enrolling by invitation
Esketamine and dexmedetomidine for recovery after lung surgery
This trial tests if adding two medicines (esketamine and dexmedetomidine) during your thoracoscopic (keyhole) lung surgery helps you recover better and feel less discomfort afterward.
Kunming, YunnanAges 18–65 - NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
Redlands, CaliforniaAges 18 years+ - NCT06853431RecruitingPhase 4
Pre-surgery calming medicine for children ages 1 to 6
This study tests a combination of two medicines (dexmedetomidine and esketamine) given as a nasal spray to help children relax before surgery. The goal is to find the best dose that works well with the least side effects.
Wenzhou, ZhejiangAges 1–6 - NCT06859892RecruitingPhase 4
Drug combo study for better sleep after major surgery
This study tests whether a combination of two medicines, dexmedetomidine and esketamine, can help improve sleep problems after major non-heart surgery. You may be eligible if you are having planned surgery lasting at least one hour and will use a pain pump after surgery.
BeijingAges 18 years+ - NCT04843982RecruitingPhase 4
Esketamine to reduce inflammation in septic adults
This trial studies whether esketamine can improve the body’s overactive inflammation during sepsis. Participants are adult ICU patients who are sick enough to need breathing support and have higher severity scores.
Wuhan, HubeiAges 18–80 - NCT06051227RecruitingPhase 3
Pain relief after injury: fentanyl vs. esketamine
This trial compares two strong pain medicines—fentanyl and esketamine—to see which works better for treating pain right after a traumatic injury. You would receive the medicine by spray in your nose or through a vein before going to the hospital.
AmsterdamAges 18 years+ - NCT06087510RecruitingPhase 4
Different doses of esketamine and dexmedetomidine for pain after scoliosis surgery
This trial tests two different doses of esketamine and dexmedetomidine to see which provides better pain relief after scoliosis correction surgery. It aims to improve your recovery and long-term outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06108830Recruiting
Esketamine and remimazolam for better sleep after surgery
This study tests whether a combination of two medicines (esketamine and remimazolam) can help people sleep better and feel less anxious after surgery. Researchers want to see if this approach works better than standard care.
TianjinAges 20–65 - NCT06389344Recruiting
Esketamine for consciousness after brain injury
This trial tests whether a medication called esketamine can help improve consciousness in people who have been in a coma or minimally conscious state after a brain injury. It is for patients who are about to have surgery, and aims to see if the drug can wake them up more.
Beijing, Beijing MunicipalityAges 16–65 - NCT06451627Recruiting
Esketamine for better sleep after spinal surgery
This study tests if a low-dose medicine called esketamine (related to ketamine) can help improve sleep after spinal surgery. It is for adults having planned spinal surgery under general anesthesia.
BeijingAges 18–65 - NCT06543563Recruiting
Esketamine for anesthesia during Parkinson's brain surgery
This trial is testing whether a drug called esketamine (related to ketamine) can help make the anesthesia experience better for people with Parkinson's disease who are undergoing a specific brain surgery called bilateral STN-DBS. If you qualify, you would receive esketamine during your procedure to see if it improves outcomes.
Beijing, Beijing MunicipalityAges 50–80 - NCT06566482RecruitingPhase 4
Medicine for pain after surgery in sleep apnea patients
This trial tests a combination of two medicines (dexmedetomidine and esketamine) given in small doses to help with pain after surgery. It is for people who have sleep apnea or are at risk for it, and who are having chest or belly surgery with a scope.
Beijing, Beijing MunicipalityAges 18–80 - NCT06773143Recruiting
Esketamine for sleep quality during breast cancer chemo
This trial tests whether a low dose of esketamine can improve sleep quality in women with breast cancer who are receiving neoadjuvant chemotherapy. If you have trouble sleeping during treatment, this study may find a new way to help.
Nanjing, JiangsuAges 18–65 - NCT06817239Recruiting
Low-dose esketamine for preventing confusion after surgery in older adults
This study tests whether a low dose of the medicine esketamine can help prevent confusion after surgery in older adults at higher risk. You may qualify if you are 65 or older, planning a major non-cardiac surgery, and have certain health conditions like high blood pressure or diabetes.
Fuzhou, FujianAges 65–90 - NCT07050212Recruiting
Sedation study for children having tonsil surgery
This study tests three different medicines to help young children relax before surgery to remove their tonsils and adenoids. It aims to find which medicine works best and is safest for kids ages 2 to 5.
Wuhan, HubeiAges 2–5 - NCT07479602RecruitingPhase 4
Medicine via nose for less pain after tonsil surgery in kids
This trial tests whether giving two medicines (dexmedetomidine and esketamine) through the nose can help children ages 3-7 have less pain after their tonsil or adenoid surgery. The goal is to find a better way to manage pain without using strong drugs.
Beijing, Beijing MunicipalityAges 3–7 - NCT06788444Recruiting
Esketamine for irritable bowel syndrome with anxiety or depression
This study tests if esketamine, a fast-acting medication, can help people with irritable bowel syndrome who also have anxiety or depression. It is given during a colonoscopy to see if it reduces your IBS symptoms.
Beijing, Beijing MunicipalityAges 18–60 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT06103760RecruitingPhase 4
Esketamine for hard-to-treat depression
This study tests whether esketamine, a nasal spray for depression, can help adults whose depression has not improved with at least two other antidepressants. Participants continue their current treatment while receiving esketamine.
St Leonards, New South WalesAges 18–65 - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Milford, ConnecticutAges 18 years+ - NCT07396220Enrolling by invitation
Psychotherapy with esketamine nasal spray for suicidal thoughts
This study tests combining a specific type of therapy (BCBT-SP) with esketamine nasal spray to help people with treatment-resistant depression who are having ongoing suicidal thoughts. The goal is to see if this combination can reduce suicidal ideation more effectively than either treatment alone.
San Diego, CaliforniaAges 18–70
What Esketamine is being studied for
Conditions with recruiting Esketamine studies.
Common questions
- Are there clinical trials studying Esketamine?
- Yes. Clin2 currently lists 56 recruiting studies that include Esketamine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Esketamine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Esketamine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Esketamine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.