KQB198 plus imatinib for advanced GIST
Part of Cancer, Digestive system clinical trials.
This trial tests a new drug called KQB198 combined with imatinib for people with advanced or metastatic gastrointestinal stromal tumor (GIST) that has a specific KIT or PDGFRA mutation. The goal is to see if this combination works better than imatinib alone as a first treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your GIST cannot be removed by surgery or has spread to other parts of the body.
- You must have a confirmed GIST diagnosis and a specific KIT or PDGFRA mutation (but not certain types like KIT exon 9 or PDGFRA D842V).
- You must have measurable tumors on a scan.
- This must be your first treatment for advanced or metastatic GIST, though you may have taken imatinib before surgery or after surgery if you stopped it over a year ago.
- You need to have good organ function and be in generally good health.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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