Testing larsucosterol for severe alcohol-related hepatitis
Part of Digestive system clinical trials.
This trial tests a new medicine called larsucosterol to see if it helps people with severe alcohol-related hepatitis (liver inflammation from heavy drinking). If you qualify, the study will monitor your safety and recovery over 90 days.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been drinking heavily (more than 40 grams of alcohol daily for women or 60 grams for men) for at least 6 months, with jaundice starting within the past 8 weeks.
- Your liver function tests show a certain pattern: total bilirubin over 3.0 mg/dL, AST between 50 and 400 IU/L, ALT under 400 IU/L, and AST/ALT ratio over 1.5.
- Your liver disease is severe enough with a Maddrey score of 32 or higher and a MELD score between 21 and 30.
- You are at least 18 years old and agree to use effective birth control if you are of childbearing potential or have a partner who could become pregnant.
- You agree to join an alcohol abstinence support program and can start the study medicine within 9 days of being admitted to the hospital.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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