Rapamycin cream for port-wine stains in children
Treatments studied
Part of Cancer clinical trials.
This study tests different doses of a cream (rapamycin) applied to part of a port-wine stain in children, combined with laser therapy. It aims to see if the cream helps fade the stain more than laser alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 10 years or younger on the day of signing up
- A port-wine stain on the face, neck, or upper chest/back that is at least 2 inches tall and 1 inch wide
- Never had more than 4 laser treatments for the stain
- Skin type I, II, III, or IV (not V or VI)
- Able to apply cream only to part of the stain and keep a diary
- Will also be having laser (PDL) treatment and the stain responds with bruising or lightening
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether using two different lasers one after the other works better than a single laser for treating port-wine stains (a type of birthmark). The goal is to see if the combination treatment can improve appearance with fewer sessions.
This Phase 2 study tests whether using a lower light dose during a treatment called Hemoporfin PDT can safely shrink port-wine birthmarks (PWB). It aims to find a dose that works well while causing fewer side effects.
This trial tests a laser treatment for vascular birthmarks (like port-wine stains). It might help if your birthmark is on an area of your body that is not the center of your face and you have light to medium skin.
This study tests how tolerable (comfortable and safe) a specific 532-nanometer laser treatment is for people with non-facial port wine stains. If you join, you’ll get laser sessions and have skin photos taken, while avoiding other treatments on the same area.
This trial studies whether rapamycin can reduce problems caused by cervico-facial or chest (mediastinal) lymphatic malformations in children. It may help with pain and swallowing or breathing difficulties when standard “curative” treatment isn’t possible.
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