Treatment
Sirolimus clinical trials
We’re tracking 107 recruiting studies that include Sirolimus, each written for real people, not researchers, below.
Recruiting studies
- NCT05036226RecruitingPhase 1/Phase 2
COAST therapy for advanced prostate or other solid tumors
This early-phase trial tests the COAST therapy approach in people with advanced solid tumor cancers or advanced prostate cancer that has continued to grow despite standard treatments. The study aims to see how well the treatment works and whether it is safe enough to continue studying.
Charleston, South CarolinaAges 18 years+ - NCT07378657RecruitingPhase 3
Sirolimus for children with orbital malformation
This trial tests if sirolimus can help children with a certain type of eye socket malformation. It aims to find a better treatment for children aged 1 to 18.
Cairo, Cairo GovernorateAges 1–18 - NCT07022587Recruiting
Dissolving stent with drug for blocked heart arteries
This trial tests a stent that slowly dissolves after opening a blocked heart artery, releasing a drug to prevent reclogging. It may help people with narrowing in one or two spots that are not too hard or twisted.
Xi'an, ShannxiAges 18–75 - NCT06727305RecruitingPhase 1/Phase 2
Sirolimus Study for Healthy Aging in Older Adults
This study tests a medication called sirolimus to see if it can help older adults stay healthy and independent. The trial is looking for people aged 65 and older who live at home and do not have serious memory problems or major health conditions like kidney or liver disease.
Dallas, TexasAges 65–80 - NCT05549167RecruitingPhase 3
Sirolimus for children with juvenile nasal blood tumors
This trial tests whether sirolimus can shrink or control juvenile nasopharyngeal angiofibroma in children and teens, and checks its safety. It may help families who cannot rely only on surgery, especially for larger or hard-to-treat tumors.
MoscowAges 7–18 - NCT02638389RecruitingPhase 3
Sirolimus for hard-to-treat vascular birthmarks
This Phase 3 study tests whether sirolimus helps control complex vascular anomalies that have not responded to standard treatments. It also checks safety by monitoring blood tests, organ function, and overall health during treatment.
Brussels, Brussels CapitalAges 3 months–70 years - NCT06236022RecruitingPhase 4
Sirolimus for dilated cardiomyopathy with KSHV infection
This trial tests whether the drug sirolimus (rapamycin) can help people with dilated cardiomyopathy who also have a specific virus (KSHV) in their blood. It aims to see if sirolimus can improve heart function.
Wuhan, HubeiAges 18–70 - NCT07844694RecruitingPhase 1
Low-dose sirolimus for patients with RUNX1 platelet disorder
This trial tests whether a low dose of sirolimus, a drug that calms the immune system, can help improve blood counts and reduce bleeding risk in people with a genetic condition called RUNX1 familial platelet disorder. If it works, it might lower the chance of developing serious blood problems later.
Portland, OregonAges 18 years+ - NCT07811024Recruiting
Strolimus-coated balloon for blocked coronary arteries
This study tests a balloon coated with a drug that may help keep arteries open after they've been cleared, especially for people with a narrowing inside a previously placed stent or in a small heart artery. It's a first-time-in-humans study to check if the treatment is safe and works.
TashkentAges 21 years+ - NCT06618248Recruiting
Sirolimus balloon for heart artery blockages at branches
This study tests a balloon coated with sirolimus (a medicine to prevent re-narrowing) to treat blockages in branch arteries of the heart. It may help patients who need a stent in the main artery but have a side branch that can be treated with this balloon instead of a stent.
Beijing, Beijing MunicipalityAges 18–85 - NCT07725380RecruitingPhase 1/Phase 2
Two drugs for relapsed sarcoma or osteosarcoma
This trial studies a new combination of two drugs, domatinostat and sirolimus, for people with sarcoma or osteosarcoma that hasn't improved after standard treatments. The goal is to see if this combination can help shrink or slow the cancer.
Tampa, FloridaAges 12–40 - NCT07728175RecruitingPhase 1
Sirolimus for Alzheimer's risk in women with ApoE4 gene
This study tests whether sirolimus, a medication that may help the body clear damaged cells, can lower Alzheimer's risk in women with the ApoE4 gene variant. It is an early-stage trial that looks at safety and how the drug affects certain blood markers.
Columbia, MissouriAges 45–65 - NCT04988685Recruiting
Heart artery balloon treatment registry study for adults
This study follows adults with blocked heart arteries who are treated using a special type of balloon (drug-coated balloon) during a procedure. It aims to track real-world outcomes to better understand how well this treatment works for people with new blockages or previously treated vessel narrowing.
Lucerne, Canton of LucerneAges 18 years+ - NCT07657793RecruitingPhase 2/Phase 3
Sirolimus for Lupus-Related Low Platelets
This trial tests sirolimus, an immune-system-calming medicine, for people with lupus who also have very low platelet counts (ITP). It may help reduce bleeding risk and improve platelet numbers.
Beijing, Beijing MunicipalityAges 18–65 - NCT07656909RecruitingPhase 2/Phase 3
Comparing low and high dose sirolimus with prednisolone for KHE with KMP
This study tests whether a low dose or a high dose of sirolimus (a drug that stops abnormal cell growth) combined with prednisolone (a steroid) works better for children with a rare, aggressive vascular tumor called KHE that also causes low blood platelets (KMP). The goal is to find the safest and most effective dose to help shrink the tumor and improve blood counts.
Chengdu, SichuanAges 1 day–18 years - NCT07581704RecruitingPhase 1
Sirolimus plus immunotherapy for relapsed multiple myeloma
This study tests whether a drug called sirolimus, given before certain immunotherapy treatments (teclistamab or talquetamab), helps these treatments work better against multiple myeloma. These immunotherapies teach your immune cells to attack myeloma cells.
Iowa City, IowaAges 18 years+ - NCT07566091Recruiting
Stent Comparison Study With Vitamin C for Heart Disease
This trial compares two drug-coated stents for treating blocked heart arteries, with or without vitamin C (ascorbic acid). It tests whether sirolimus plus vitamin C is as safe and effective as everolimus. If you need a stent, this study may help determine which medication coating works best for you.
SeoulAges 19 years+ - NCT06091332RecruitingPhase 2
Sirolimus for brainstem cavernoma bleeding
This trial tests if sirolimus, a medicine that may help reduce abnormal blood vessels, can prevent another brain bleed in people who recently had a bleed from a brainstem cavernoma. You would receive either sirolimus or a placebo to see if it works.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT02432560Recruiting
Testing sirolimus for long-term treatment of LAM
This trial studies whether sirolimus can be used safely and works over time for LAM, a rare lung disease. You may be able to join if you already use (or cannot use) certain lung-targeting medicines called mTOR inhibitors, and if you can do regular clinic visits and breathing tests.
Stanford, CaliforniaAges 18 years+ - NCT06673290RecruitingPhase 2/Phase 3
Testing different doses of sirolimus for cystic lymphatic malformations
This trial tests different doses of sirolimus (a medication that slows cell growth) to find the best dose for treating cystic lymphatic malformations in children. It may help shrink the abnormal fluid-filled growths and improve symptoms.
Chengdu, SichuanAges 1–18 - NCT06856200Recruiting
Sirolimus plus palbociclib and fulvestrant for advanced breast cancer
This trial tests a new combination of three drugs (sirolimus, palbociclib, and fulvestrant) for people with a certain type of advanced breast cancer that is hormone receptor-positive and HER2-negative. The goal is to see if adding sirolimus can help control the cancer when standard hormone therapy is no longer working.
ShanghaiAges 18 years+ - NCT07256249Recruiting
Registry studying a drug-coated balloon for coronary artery disease
This trial is tracking the long-term safety and effectiveness of a sirolimus-eluting balloon (Selution SLR) in people with coronary artery disease. It aims to see how well this device works when used to open blocked arteries in real-world medical practice.
AmadoraAges 18 years+ - NCT07241936RecruitingPhase 1/Phase 2
Sirolimus plus ADC drugs for advanced solid tumors
This trial tests a new type of sirolimus (a targeted therapy) combined with antibody-drug conjugates (ADCs) for advanced solid tumors that haven't responded to other treatments. It aims to see if the combination can shrink tumors or slow their growth.
ShanghaiAges 18–75 - NCT07165886RecruitingPhase 2/Phase 3
Study of sirolimus and octreotide for advanced neuroendocrine tumors
This trial tests a combination of two drugs, sirolimus and octreotide, for people with advanced neuroendocrine tumors in the digestive system that cannot be removed by surgery and are not making excess hormones. The goal is to see if this combination can help control the tumors.
Beijing, Beijing MunicipalityAges 18 years+
What Sirolimus is being studied for
Conditions with recruiting Sirolimus studies.
Common questions
- Are there clinical trials studying Sirolimus?
- Yes. Clin2 currently lists 107 recruiting studies that include Sirolimus, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Sirolimus trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Sirolimus an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Sirolimus or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.