Progestin therapy before hysterectomy for endometrial cancer
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This trial tests whether taking progestin (a hormone medication) before scheduled surgery can improve outcomes for women with a type of uterine cancer called endometrioid adenocarcinoma. You might be able to join if you are planning to have a hysterectomy and are open to hormone therapy before the procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of endometrioid endometrial cancer (the most common type of uterine cancer) from a biopsy within the last 8 weeks.
- You are at least 18 years old and scheduled for surgery to remove your uterus.
- Your kidney and liver function are within a safe range based on recent blood tests.
- You have adequate blood cell counts (platelets and white blood cells) as shown on recent labs.
- You have not had prior hormone therapy (like progestin or anti-estrogen) for this cancer in the last 3 months, and no prior cancer treatment for uterine cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study looks at women with endometrial adenocarcinoma or atypical hyperplasia who had conservative treatment instead of radical surgery. It aims to check how well the treatment works for both cancer and future pregnancy outcomes.
This Phase 2 study tests whether a lifestyle transformation can help treat complex atypical endometrial hyperplasia or early (grade 1) endometrial cancer without removing the uterus. It may help support uterine preservation for people who want to keep fertility or avoid hysterectomy.
This trial tests whether combining two hormone medicines can treat early endometrial (uterine) cancer while helping preserve the uterus and future fertility. You may be eligible if your cancer is early and limited, with no spread seen on scans, and you can safely take these medicines.
This trial tests if giving hormone-blocking pills before surgery can help guide which treatments you need after surgery. It is for premenopausal women with early-stage, hormone-sensitive breast cancer.
This trial tests whether adding GnRH medicine and letrozole to standard progestin treatment can better control early, low-risk endometrial cancer or atypical hyperplasia in people who are not obese. It may help some patients avoid progression while keeping the uterus, especially for those wanting future fertility.
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