A study of two drugs for KRAS G12D tumors
Part of Cancer clinical trials.
This trial tests two experimental drugs (IN10018 and RNK08954) together for people with advanced solid tumors that have a specific KRAS G12D mutation. The goal is to see if this combination can shrink tumors when standard treatments have stopped working.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a solid tumor that has spread or cannot be removed by surgery.
- Your tumor must have a specific genetic change called KRAS G12D (confirmed by a lab test).
- You must have tried standard treatments and they either didn't work or you couldn't take them.
- You must be 18 years or older and generally able to care for yourself (ECOG score 0 or 1).
- You must have at least one tumor that can be measured on a CT or MRI scan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early-stage trial tests a new drug called INV-8989 designed to target a specific genetic mutation (KRAS G12D) found in some advanced solid cancers. The study will evaluate whether the drug is safe and if it can help shrink tumors in patients who haven't responded to standard treatments.
This trial tests a new oral drug called RNK08954 for people with advanced solid tumors that have a specific KRAS G12D genetic change. The drug targets this mutation to try to stop tumor growth. It is for patients who have already had other treatments and may not have many options left.
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