CAR-T cell therapy for hard-to-treat lupus
Part of Immune system & allergy, Skin clinical trials.
This trial tests a new CAR-T cell therapy for people with severe lupus that hasn't improved with standard treatments. The therapy uses specially designed immune cells to target and destroy cells causing the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with systemic lupus erythematosus (SLE).
- Your lupus has not responded well to at least two different immune-suppressing medicines, including a B-cell depleting drug like rituximab or belimumab.
- You have active lupus with a certain level of disease activity (SLEDAI-2K score of 6 or more), or severe low platelet counts from lupus.
- Your blood tests show specific lupus antibodies, such as ANA or anti-dsDNA.
- You have adequate kidney, liver, and bone marrow function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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