Can vasodilators help with chemo side effects in GI cancer?
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests two drugs (isosorbide mononitrate and diltiazem) to see if they can prevent blood vessel damage caused by chemotherapy drugs like 5-FU or capecitabine in people with gastrointestinal cancers.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a gastrointestinal cancer (like colon, rectal, stomach, or esophageal) and are about to start chemotherapy with 5-FU or capecitabine.
- Your blood pressure and heart rate are at certain levels (systolic blood pressure at least 120 and resting heart rate at least 70).
- You have not had a heart attack in the last 6 months or have severe heart failure.
- You are not taking certain heart medications (like nitrates or calcium channel blockers) or have allergies to them.
- You are able to return to the clinic for tests and take study pills as directed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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