Clin2
NCT07469982Likely a fitRecruiting

Study of SY-9453 for advanced solid tumors

Advanced or Metastatic Solid Tumors With Homozygous MTAP Deletion

Part of Cancer clinical trials.

This trial tests an experimental pill called SY-9453 for people with advanced solid tumors that have a specific genetic change (MTAP deletion). The goal is to see if it is safe and how the body processes it. It may be an option if you have tried standard treatments without success.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
122 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have an advanced solid tumor that has progressed or is not responding to standard treatments, or there is no standard treatment available.
  • A recent test shows your tumor has lost both copies of a gene called MTAP (or you are willing to provide a tissue sample for this testing).
  • You are able to carry out daily activities with little or no help (ECOG score 0 or 1).
  • Your kidney, liver, and blood counts are within acceptable limits based on recent lab tests.
  • You have not had certain other cancer treatments within the past few weeks, and any side effects from past treatments have mostly resolved.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

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