Screening for brain metastases in high-risk cancers
Treatments studied
Part of Cancer, Lungs & breathing, Skin clinical trials.
This study uses MRI scans to look for cancer that has spread to the brain in people with certain types of breast cancer, lung cancer, or melanoma. The goal is to find brain metastases early, when they may be easier to treat.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with HER2-positive or triple-negative breast cancer, non-small cell lung cancer, or melanoma.
- Your cancer is at a stage that puts you at high risk for spreading to the brain (stage IV breast cancer or melanoma, or stage II-IV lung cancer).
- You are 18 years or older.
- You are generally able to care for yourself (Karnofsky score of 60 or higher).
- You do not have severe kidney, heart, or liver problems.
- You can undergo MRI scans, including with contrast dye, and are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is looking at whether routine brain scans (MRI) at the time of diagnosis of metastatic breast cancer can help detect brain metastases early, even before they cause symptoms. It aims to understand how common brain metastases are in high-risk breast cancer and whether early detection can help guide treatment decisions. This may be relevant for people with certain types of breast cancer that have spread to other organs.
This trial uses an MRI scan to look for early signs of breast cancer spreading to the brain in people with certain aggressive breast cancer types (triple-negative or HER2-positive) that are stage IIb or III. The goal is to find and treat brain metastases earlier, before they cause symptoms.
This trial checks whether taking screening brain MRI scans in people with stage IV breast cancer helps find brain involvement earlier. It may help guide treatment decisions for those who would otherwise only get brain imaging after symptoms start.
This trial looks at whether doing an MRI scan of the brain for people with stage IV lung cancer helps in their care. The goal is to find brain issues early (if present) so treatment decisions can be made sooner.
This study tests a new MRI sequence to see if it can better detect brain metastases. You may be eligible if you are scheduled for a brain MRI with contrast and have known or suspected brain metastases.
This study tests whether regular brain scans (surveillance) help spot brain metastases early in people with HER2-positive breast cancer that has spread to other parts of the body. Participation involves being randomly assigned to either routine brain scans or no extra scans to see which approach is better.
Hear when a new Lung Cancer Stage IV trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.