Study of immunotherapy plus chemo and radiation for advanced stomach cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) with chemotherapy (SOX) and targeted radiation for people with advanced stomach or gastroesophageal junction cancer that hasn't been treated yet. The goal is to see if this approach helps shrink tumors or slow the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery and has not spread to other parts of the body after prior treatment.
- Your cancer is HER2-negative (a type of protein not found on the tumor cells).
- You have at least one tumor that can be measured on scans and is suitable for radiation therapy.
- You have not had any prior systemic therapy (like chemotherapy or immunotherapy) for advanced disease, and if you had earlier treatment with curative intent, it ended at least 6 months ago.
- You are in good overall health (able to perform daily activities without help) and have normal organ function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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