Immunotherapy combo for advanced stomach cancer after first treatment
Part of Cancer, Digestive system clinical trials.
This trial tests a new combination of two immunotherapy drugs (iparomlimab and tuvonralimab) with a chemotherapy drug (albumin-bound paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has progressed after first-line treatment. The goal is to see if this combination can help shrink tumors or slow cancer growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have advanced stomach or gastroesophageal junction cancer confirmed by biopsy.
- Your cancer has gotten worse or you couldn't tolerate your first treatment, which included a platinum drug (like oxaliplatin or cisplatin) and a fluorouracil-type drug (like 5-FU, capecitabine, or S-1).
- You have at least one tumor that can be measured on scans.
- Your organs (like bone marrow, liver, and kidneys) are working well enough, as shown by blood tests.
- You do not have HER2-positive cancer, active autoimmune disease, or have not previously received a PD-1/CTLA-4 bispecific antibody or taxane chemotherapy as your first treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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